Teno, J.; Pardo-Figuerez, M.; Evtoski, Z.; Prieto, C.; Cabedo, L.; Lagaron, J.M. Development of Ciprofloxacin-Loaded Electrospun Yarns of Application Interest as Antimicrobial Surgical Suture Materials. Pharmaceutics2024, 16, 220.
Teno, J.; Pardo-Figuerez, M.; Evtoski, Z.; Prieto, C.; Cabedo, L.; Lagaron, J.M. Development of Ciprofloxacin-Loaded Electrospun Yarns of Application Interest as Antimicrobial Surgical Suture Materials. Pharmaceutics 2024, 16, 220.
Teno, J.; Pardo-Figuerez, M.; Evtoski, Z.; Prieto, C.; Cabedo, L.; Lagaron, J.M. Development of Ciprofloxacin-Loaded Electrospun Yarns of Application Interest as Antimicrobial Surgical Suture Materials. Pharmaceutics2024, 16, 220.
Teno, J.; Pardo-Figuerez, M.; Evtoski, Z.; Prieto, C.; Cabedo, L.; Lagaron, J.M. Development of Ciprofloxacin-Loaded Electrospun Yarns of Application Interest as Antimicrobial Surgical Suture Materials. Pharmaceutics 2024, 16, 220.
Abstract
Surgical site infections (SSI) occur very frequently during post-operatory procedures and are often treated with oral antibiotics, which may cause some side-effects. This type of infections could be avoided by encapsulating antimicrobial/anti-inflammatory drugs within the surgical suture materials so that these can more efficiently act on the site of action during wound closure, avoiding post-operatory bacterial infection and spreading. This work was aimed at developing novel electrospun biobased anti-infective fiber-based yarns as novel suture materials for preventing surgical site infections. For this, yarns based on flying intertwined nanofibers were fabricated in-situ during the electrospinning process using a specially designed yarn collector. The electrospun yarn sutures were made of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) with different contents of 3HV units and contained ciprofloxacin hydrochloride (CPX) as the antimicrobial active pharmaceutical ingredient (API). The yarns were then analyzed by scanning electron microscopy, Fourier transform infrared spectroscopy, wide-angle X-ray scattering, differential scanning calorimetry and in vitro drug release. The yarns were also analyzed in terms of antimicrobial and mechanical properties. The material characterization indicated that the varying polymer molecular architecture affected the attained polymer crystallinity, which was correlated with the different drug-eluting profiles. Moreover, the materials exhibited the inherent stiff behavior of PHBV, which was further enhanced by the API. Lastly, all the yarn sutures presented antimicrobial properties for a time release of 5 days against both gram positive and gram-negative pathogenic bacteria. The results presented highlight the potential of the herein developed antimicrobial electrospun fiber yarns as potential innovative suture materials to prevent surgical infections.
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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