PreprintReviewVersion 1Preserved in Portico This version is not peer-reviewed
Design Features, Quality by Design Approach, Characterization, Therapeutic Applications and Clinical Considerations of Transdermal Therapeutic Systems – A Comprehensive Review
Version 1
: Received: 7 January 2024 / Approved: 8 January 2024 / Online: 8 January 2024 (06:41:04 CET)
How to cite:
Sivadasan, D. Design Features, Quality by Design Approach, Characterization, Therapeutic Applications and Clinical Considerations of Transdermal Therapeutic Systems – A Comprehensive Review. Preprints2024, 2024010524. https://doi.org/10.20944/preprints202401.0524.v1
Sivadasan, D. Design Features, Quality by Design Approach, Characterization, Therapeutic Applications and Clinical Considerations of Transdermal Therapeutic Systems – A Comprehensive Review. Preprints 2024, 2024010524. https://doi.org/10.20944/preprints202401.0524.v1
Sivadasan, D. Design Features, Quality by Design Approach, Characterization, Therapeutic Applications and Clinical Considerations of Transdermal Therapeutic Systems – A Comprehensive Review. Preprints2024, 2024010524. https://doi.org/10.20944/preprints202401.0524.v1
APA Style
Sivadasan, D. (2024). Design Features, Quality by Design Approach, Characterization, Therapeutic Applications and Clinical Considerations of Transdermal Therapeutic Systems – A Comprehensive Review. Preprints. https://doi.org/10.20944/preprints202401.0524.v1
Chicago/Turabian Style
Sivadasan, D. 2024 "Design Features, Quality by Design Approach, Characterization, Therapeutic Applications and Clinical Considerations of Transdermal Therapeutic Systems – A Comprehensive Review" Preprints. https://doi.org/10.20944/preprints202401.0524.v1
Abstract
Transdermal drug delivery systems (TDDS) are designed to administer a consistent and effective dose of medication through the patient's skin. These pharmaceutical preparations are self-contained, discrete dosage forms designed to be placed topically on intact skin to release the active component at a controlled rate by penetrating the skin barriers. This medication provides a continuous and prolonged administration of a substance at a consistent rate. TDDS, or transdermal drug delivery system, has gained significant attention as a non-invasive method of administering drugs to vulnerable patient populations, such as pediatric and geriatric patients. This approach is considered easy to administer and helps overcome bioavailability issues associated with conventional drug delivery, which can be hindered by poor absorption and metabolism. TDDS has various advantages compared to conventional methods of drug administration. It is less intrusive, more patient-friendly, and can circumvent first-pass metabolism and the corrosive acidic environment of the stomach that happens when medications are taken orally. Multiple methodologies have been devised to augment the transdermal permeability of diverse pharmaceutical substances. Recent advancements in transdermal drug delivery systems have facilitated the precise delivery of medications to the intended site of action by improving the penetration of drugs through the outermost layer of the skin, known as the stratum corneum, resulting in enhanced drug availability throughout the body. This review seeks to provide a concise overview of the several methods employed in the production of TDDS, as well as their evaluation, therapeutic uses, clinical considerations, and current advancements. These advancements have resulted in the development of intelligent, biodegradable, and highly efficient transdermal drug delivery systems.
Keywords
transdermal drug delivery system; skin permeation; permeation enhancers; quality by design ap-proach; therapeutic applications
Subject
Biology and Life Sciences, Life Sciences
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
