Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Identification of Alzheimer’s Disease by Molecular Imaging: Progress and Prospects

Liwei Xing
,
Xiaoman Lv
,
Yiting Guo
,
Chengting Jiang
,
Meng Li
ORCID logo ,
Mengjia Yang
,
Rui Guo
,
Xianhu Zhu
,
Xiahuang Li
* ,
Hongling Shi
* ,
Dongdong Qin
* ORCID logo
Version 1 : Received: 4 January 2024 / Approved: 5 January 2024 / Online: 5 January 2024 (14:24:20 CET)

How to cite: Xing, L.; Lv, X.; Guo, Y.; Jiang, C.; Li, M.; Yang, M.; Guo, R.; Zhu, X.; Li, X.; Shi, H.; Qin, D. Identification of Alzheimer’s Disease by Molecular Imaging: Progress and Prospects. Preprints 2024, 2024010477. https://doi.org/10.20944/preprints202401.0477.v1 Xing, L.; Lv, X.; Guo, Y.; Jiang, C.; Li, M.; Yang, M.; Guo, R.; Zhu, X.; Li, X.; Shi, H.; Qin, D. Identification of Alzheimer’s Disease by Molecular Imaging: Progress and Prospects. Preprints 2024, 2024010477. https://doi.org/10.20944/preprints202401.0477.v1

Abstract

Alzheimer's disease (AD), which is characterized by the development of β-amyloid plaques and neurofibrillary tangles in the brain parenchyma, can result in synaptic and neuronal loss. Clinical signs, including deteriorating memory deficiency, may lead to catastrophic effects for the elderly. Research on brain imaging and its application in the study of AD has advanced extraordinarily over the past 30 years. However, widely used imaging methods are only capable of identifying structural or metabolic alterations at the anatomical level in the brain and can only be utilized for drawing inferential distinctions. As a disease with a complex pathophysiological mechanism, AD has many different molecular pathological features and molecular biomarkers. Therefore, molecular imaging for AD pathology indicators provides a practical method for the early diagnosis and impartial assessment of AD. The present review discusses the pathogenesis of AD, as well as the detection methods and principles of molecular imaging, such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT) techniques. Meanwhile, various tracers and probes applied in molecular imaging that detect Aβ deposits, tau protein accumulation, and neurotransmitters are also reviewed. Molecular pathological tracers provide the possibility to accurately quantify brain changes through molecular imaging.

Keywords

Alzheimer's disease; Molecular Imaging; pathogenesis; diagnosis; treatments

Subject

Biology and Life Sciences, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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