Version 1
: Received: 28 December 2023 / Approved: 4 January 2024 / Online: 4 January 2024 (14:13:35 CET)
How to cite:
Montanari, M.; Meringolo, M.; El Atiallah, I.; Renna, A.; Martella, G. Two Sides of the Same Coin: Genes Involved in Neurodegeneration and Cancer. Preprints2024, 2024010419. https://doi.org/10.20944/preprints202401.0419.v1
Montanari, M.; Meringolo, M.; El Atiallah, I.; Renna, A.; Martella, G. Two Sides of the Same Coin: Genes Involved in Neurodegeneration and Cancer. Preprints 2024, 2024010419. https://doi.org/10.20944/preprints202401.0419.v1
Montanari, M.; Meringolo, M.; El Atiallah, I.; Renna, A.; Martella, G. Two Sides of the Same Coin: Genes Involved in Neurodegeneration and Cancer. Preprints2024, 2024010419. https://doi.org/10.20944/preprints202401.0419.v1
APA Style
Montanari, M., Meringolo, M., El Atiallah, I., Renna, A., & Martella, G. (2024). Two Sides of the Same Coin: Genes Involved in Neurodegeneration and Cancer. Preprints. https://doi.org/10.20944/preprints202401.0419.v1
Chicago/Turabian Style
Montanari, M., Alessandro Renna and Giuseppina Martella. 2024 "Two Sides of the Same Coin: Genes Involved in Neurodegeneration and Cancer" Preprints. https://doi.org/10.20944/preprints202401.0419.v1
Abstract
Abstract The relationship between cancer and neurodegeneration has spurred extensive scientific discourse, challenging their historical classification as distinct disorders. While cancer signifies uncontrolled cellular proliferation and neurodegeneration marks progressive neuronal loss, recent insights highlight intriguing interconnections between these seemingly disparate conditions. Cancer entails perpetual signaling for growth, evasion of growth inhibitors, resistance to cell death, acquisition of replicative immortality, stimulation of blood vessel growth (angiogenesis), and initiation of invasion and metastasis. Conversely, investigations emphasize disrupted cellular energy regulation and evasion of immune surveillance as key traits arising from genome instability, mutations, and inflammation driving tumorigenesis. Neurodegeneration involves neuronal malfunction and depletion, synaptic impairment, and protein abnormalities aggregations contributing to muscle atrophy and cognitive deficits. Varied clinical studies underscore contrasting correlations between cancer and neurodegeneration, hinting at mirrored molecular pathways that foster cell resilience or vulnerability. Research explores cellular signaling in tumorigenesis, shared with neurodegenerative disorders. Aberrant expression or mutations in crucial genes implicated in neurodegeneration also surface in cancer contexts. Debates persist on the nature of the relationship between cancer and neurodegeneration, contemplating inverse associations or shared pathways. Understanding their complex interplay, encompassing genetics, cellular mechanisms, and environmental influences, remains pivotal in unraveling their connections. This review explores the intriguing perspective that neurodegeneration and cancer might share fundamental genetic links, delving into potential implications for their onset and progression.
Keywords
Neurodegeneration; inflammation; cancer; Parkinson's Disease; neuron; cell biology; interleukins; disease progression; genetic and somatic mutations; double hit hypothesis
Subject
Biology and Life Sciences, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
