Version 1
: Received: 4 January 2024 / Approved: 4 January 2024 / Online: 4 January 2024 (12:35:27 CET)
How to cite:
Kim, S.-J.; Moon, J. Safe Pigs for Xenotransplantation: Characteristics and Diagnostic Methods of Vertical Transmissible Viruses. Preprints2024, 2024010387. https://doi.org/10.20944/preprints202401.0387.v1
Kim, S.-J.; Moon, J. Safe Pigs for Xenotransplantation: Characteristics and Diagnostic Methods of Vertical Transmissible Viruses. Preprints 2024, 2024010387. https://doi.org/10.20944/preprints202401.0387.v1
Kim, S.-J.; Moon, J. Safe Pigs for Xenotransplantation: Characteristics and Diagnostic Methods of Vertical Transmissible Viruses. Preprints2024, 2024010387. https://doi.org/10.20944/preprints202401.0387.v1
APA Style
Kim, S. J., & Moon, J. (2024). Safe Pigs for Xenotransplantation: Characteristics and Diagnostic Methods of Vertical Transmissible Viruses. Preprints. https://doi.org/10.20944/preprints202401.0387.v1
Chicago/Turabian Style
Kim, S. and Joonho Moon. 2024 "Safe Pigs for Xenotransplantation: Characteristics and Diagnostic Methods of Vertical Transmissible Viruses" Preprints. https://doi.org/10.20944/preprints202401.0387.v1
Abstract
Amid the deepening imbalance in the supply and demand of allogeneic organs, xenotransplanta-tion can be a practical alternative because it makes an unlimited supply of organs possible. How-ever, to perform xenotransplantation on patients, the source animals to be used must be free from infectious agents. This requires breeding of animals using assisted reproductive techniques, such as somatic cell nuclear transfer, embryo transfer, and cesarean-section, without colostrum de-rived in designated pathogen-free (DPF) facilities. Most infectious agents can be removed from animals produced by these methods, but several viruses known to pass through the placenta are not easy to remove, even with these methods. Therefore, in this review, we look at the characteris-tics of several viruses known to cross the placenta and determine how they can be detected. This review is intended to help maintain DPF facilities by preventing animals infected with the virus from entering DPF facilities and to help select pigs suitable for xenotransplantation.
Biology and Life Sciences, Animal Science, Veterinary Science and Zoology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
