Bartoszewska, E.; Molik, K.; Choromańska, A.; Woźniak, M. Telomerase Inhibition Potential of Natural Compounds in Leukemia Treatment. Preprints2024, 2024010362. https://doi.org/10.20944/preprints202401.0362.v1
APA Style
Bartoszewska, E., Molik, K., Choromańska, A., & Woźniak, M. (2024). Telomerase Inhibition Potential of Natural Compounds in Leukemia Treatment. Preprints. https://doi.org/10.20944/preprints202401.0362.v1
Chicago/Turabian Style
Bartoszewska, E., Anna Choromańska and Marta Woźniak. 2024 "Telomerase Inhibition Potential of Natural Compounds in Leukemia Treatment" Preprints. https://doi.org/10.20944/preprints202401.0362.v1
Abstract
Leukemia encompasses diverse blood cancers marked by the unchecked growth and developmental blockage of myeloid or lymphoid precursor cells within the bone marrow and the bloodstream. Treatment traditionally involves intensive chemotherapy or hematopoietic stem cell transplantation, albeit these approaches often yield severe side effects and encounter resistance from leukemia cells. Hence, the quest for novel therapies targeting leukemic cells selectively is paramount to enhancing leukemia outcomes. Exploring natural products is a promising avenue for pursuing effective chemotherapy and preventive measures against leukemia. These compounds serve as a crucial wellspring for drug development and offer a source of biologically active elements for potential therapeutic interventions in leukemia. The enzyme telomerase plays a vital role in stabilizing chromosomes by adding DNA sections to the end of chromosomes during the mitotic cycle. Notably, hTERT mRNA expression strongly correlates with telomerase activity, making it a potential target for therapeutic intervention without adverse systemic effects. Telomerase inhibition is a promising target in cancer therapy, especially in combination with natural ingredients, demonstrating less cytotoxicity than chemotherapies.
Keywords
leukemia; natural substances; telomerase; antioxidant; hematological malignancy; genomic instability; DNA damage; polyphenols; vitamins; in vitro; in vivo and clinical trials
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
