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Spray-Drying Microencapsulation of Phenolic Compounds from Bauhinia ungulata L. Var. Obtusifolia Aqueous Extract: A Comparative Study Using Different Wall Materials
Remígio, M.S.N.; Greco, T.; Silva Júnior, J.O.C.; Converti, A.; Ribeiro-Costa, R.M.; Rossi, A.; Barbosa, W.L.R. Spray-Drying Microencapsulation of Bauhinia ungulata L. var. obtusifolia Aqueous Extract Containing Phenolic Compounds: A Comparative Study Using Different Wall Materials. Pharmaceutics2024, 16, 488.
Remígio, M.S.N.; Greco, T.; Silva Júnior, J.O.C.; Converti, A.; Ribeiro-Costa, R.M.; Rossi, A.; Barbosa, W.L.R. Spray-Drying Microencapsulation of Bauhinia ungulata L. var. obtusifolia Aqueous Extract Containing Phenolic Compounds: A Comparative Study Using Different Wall Materials. Pharmaceutics 2024, 16, 488.
Remígio, M.S.N.; Greco, T.; Silva Júnior, J.O.C.; Converti, A.; Ribeiro-Costa, R.M.; Rossi, A.; Barbosa, W.L.R. Spray-Drying Microencapsulation of Bauhinia ungulata L. var. obtusifolia Aqueous Extract Containing Phenolic Compounds: A Comparative Study Using Different Wall Materials. Pharmaceutics2024, 16, 488.
Remígio, M.S.N.; Greco, T.; Silva Júnior, J.O.C.; Converti, A.; Ribeiro-Costa, R.M.; Rossi, A.; Barbosa, W.L.R. Spray-Drying Microencapsulation of Bauhinia ungulata L. var. obtusifolia Aqueous Extract Containing Phenolic Compounds: A Comparative Study Using Different Wall Materials. Pharmaceutics 2024, 16, 488.
Abstract
Species belonging to the Bauhinia genus, usually known as "pata-de-vaca", are popularly used to treat diabetes. Among them is Bauhinia ungulata var. obtusifolia (Ducke) Vaz, whose leaves are used, as a tea, for medicinal purposes in the Amazon region. The microencapsulation of the aqueous extract of its leaves, containing phenolic compounds, using five different wall materials (maltodextrin: DE11-14, and DE4-7; β-cyclodextrin; pectin, and sodium carboxymethylcellulose) is described in this paper. The microstructure, particle size, thermal behavior, yield, and encapsulation efficiency were investigated and compared using different techniques. Using high-performance liquid chromatography, phenolics, and flavonoids were detected and quantified in the microparticles. Microparticles, obtained with yield and phenolics encapsulation efficiency ranging between 60-83 % and 35-57 %, respectively, showed a particle size distribution between 1.15 and 5.54 µm, spherical morphology, and wrinkled surface. Among them, those prepared with sodium carboxymethylcellulose and pectin proved to be thermally the most stable. They had the highest flavonoid content (23.07 and 21.73 mgRUTE/g Extract) and total antioxidant activity by both the DPPH· (376.55 and 367.86 µmolTrolox/g Extract) and ABTS·+ (1085.72 and 1062.32 µmolTrolox/ g Extract) assays. The chromatographic analyses allowed for quantification, in the microparticles, chlorogenic acid (1.67-1.98 mg/g Extract), p-coumaric acid (0.06-0.08 mg/g Extract), rutin (11.1-12.9 mg/g Extract) and isoquercitrin (0.47-0.53 mg/g Extract), compounds considered responsible for the antidiabetic property attributed to the species.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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