Review
Version 1
Preserved in Portico This version is not peer-reviewed
Haemophilia and Cancer: A Systematic Review
Version 1
: Received: 3 January 2024 / Approved: 4 January 2024 / Online: 4 January 2024 (03:47:09 CET)
A peer-reviewed article of this Preprint also exists.
Zanon, E.; Porreca, A.; Simioni, P. Haemophilia and Cancer: A Literature Review. J. Clin. Med. 2024, 13, 1770. Zanon, E.; Porreca, A.; Simioni, P. Haemophilia and Cancer: A Literature Review. J. Clin. Med. 2024, 13, 1770.
Abstract
Background: Opinions on the impact of cancer on patients with haemophilia literature are contradicting. There is a lack of data on the clinical presentation and management of cancer in patients with haemophilia (PWH). Methods: Papers were found following a comprehensive search in PubMed, Google Scholar, and Scopus using the terms “cancer” and “haemophilia” without time limits and using the English language as a filter. The references of all retrieved original articles and reviews were assessed for additional relevant articles. Results: Overall, 116 papers were collected. Managing cancer in patients with congenital bleeding disorders, such as haemophilia A and B, requires careful evaluation of bleeding risk and the effect of antitumor treatments on blood coagulation. Generally, patients with haemophilia do not have an increased risk of developing cancer compared to the general population; increased risk is found in the presence of HIV or hepatitis infection. However, if a patient with haemophilia develops cancer, the treatment must be managed to minimise the risk of bleeding. Bleeding and thrombotic complications are important causes of morbidity and mortality in critically ill patients with cancer; replacement therapy with factor VIII or IX or others should be maintained during antitumor treatment. Conclusion: Overall, managing cancer in patients with haemophilia requires careful evaluation and individualised planning involving a multidisciplinary team of physicians experienced in haematology, oncology, and surgery.
Keywords
haematology; haemophilia; cancer; malignancy; congenital bleeding disorders
Subject
Medicine and Pharmacology, Hematology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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