Comparison of PIV and Other Immune Inflammation Markers of Oncological and Survival Outcomes in Patients Undergoing Radical Cystectomy

Pierluigi Russo; Giuseppe Palermo; Roberto Iacovelli; Mauro Ragonese; Chiara Ciccarese; Giuseppe Maioriello; Fabrizio Fantasia; Francesco Pio Bizzarri; Filippo Marino; Seyed Koosha Moosavi; Domenico Nigro; Filippo Gavi; Giovanni Battista Filomena; Francesco Rossi; Francesco Pinto; Marco Racioppi; Nazario Foschi

doi:10.20944/preprints202401.0298.v1

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preprints.org > medicine and pharmacology > urology and nephrology > doi: 10.20944/preprints202401.0298.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Comparison of PIV and Other Immune Inflammation Markers of Oncological and Survival Outcomes in Patients Undergoing Radical Cystectomy

^* ,

Francesco Pio Bizzarri

Giovanni Battista Filomena

Version 1 : Received: 29 December 2023 / Approved: 4 January 2024 / Online: 4 January 2024 (15:17:24 CET)

A peer-reviewed article of this Preprint also exists.

Russo, P.; Palermo, G.; Iacovelli, R.; Ragonese, M.; Ciccarese, C.; Maioriello, G.; Fantasia, F.; Bizzarri, F.P.; Marino, F.; Moosavi, K.; Nigro, D.; Filomena, G.B.; Gavi, F.; Rossi, F.; Pinto, F.; Racioppi, M.; Foschi, N. Comparison of PIV and Other Immune Inflammation Markers of Oncological and Survival Outcomes in Patients Undergoing Radical Cystectomy. Cancers 2024, 16, 651. Russo, P.; Palermo, G.; Iacovelli, R.; Ragonese, M.; Ciccarese, C.; Maioriello, G.; Fantasia, F.; Bizzarri, F.P.; Marino, F.; Moosavi, K.; Nigro, D.; Filomena, G.B.; Gavi, F.; Rossi, F.; Pinto, F.; Racioppi, M.; Foschi, N. Comparison of PIV and Other Immune Inflammation Markers of Oncological and Survival Outcomes in Patients Undergoing Radical Cystectomy. Cancers 2024, 16, 651.

Abstract

Inflammation is widely acknowledged as a significant characteristic of cancer, playing a substantial function in both the initiation and advancement of cancers. In this research, we planned to investigate the comparison among pan-immune inflammation markers and other well-known markers (systemic immune inflammation index and neutrophil to lymphocyte ratio) to predict prognosis in individuals treated with radical cystectomy for bladder cancer. Methods: In this retrospective analysis, we focused on preoperative PIV, systemic immune inflammation index (SII), and neutrophil-lymphocyte ratio (NLR) in 193 individuals managed with radical cystectomy for bladder cancer between January 2016 and November 2022. Multivariable logistic regression assessments were perfomred to assess the predictive capabilities of PIV, SII, and NLR for infiltration of lymph nodes (N), aggressive tumor stage (pT3/pT4), and any non-organ limited disease at the time of RC. Multivariable Cox regression analyses were conducted to assess the predictive impact of PIV on Relapse-free survival (RFS), Cancer-specific survival (CSS), and Overall survival (OS). Results: Our individuals were divided into high PIV and low PIV cohorts using the optimal cut-off value (340.96 x 109/ L) based on receiver operating characteristic curve analysis for relapse-free survival. In multivariable preoperative logistic regression models, only SII and PIV correlated with the infiltration of lymph nodes, aggressive disease, and any non-organ confined disease. In multivariable Cox regression models considering presurgical clinicopathological variables, an higher PIV was associated with diminished RFS (p = 0.017) and OS (p = 0.029). In addition, in multivariable Cox regression models for postoperative outcomes, a high PIV correlated with both RFS ( p = 0.034) and OS ( p= 0.048). Conclusions: Our study suggests that PIV and SII are two very similar markers that may serve as an independent and significant predictor of aggressive disease and worse survival impacts on individuals undergoing radical cystectomy for bladder neoplasm.

Keywords

urothelial carcinoma; inflammation; pan-immune inflammation value; radical cystectomy

Subject

Medicine and Pharmacology, Urology and Nephrology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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