Dynamics of Histone Modifications during Mammalian Zygotic Genome Activation

Francisco Sotomayor-Lugo; Nataly Iglesias-Barrameda; Yandy Marx Castillo-Aleman; Imilla Casado-Hernandez; Carlos Agustin Villegas-Valverde; Antonio Alfonso Bencomo-Hernandez; Yendry Ventura-Carmenate; Rene Antonio Rivero-Jimenez

doi:10.20944/preprints202401.0113.v1

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preprints.org > biology and life sciences > biochemistry and molecular biology > doi: 10.20944/preprints202401.0113.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Dynamics of Histone Modifications during Mammalian Zygotic Genome Activation

Francisco Sotomayor-Lugo

Nataly Iglesias-Barrameda

Yandy Marx Castillo-Aleman

Imilla Casado-Hernandez

Carlos Agustin Villegas-Valverde

Antonio Alfonso Bencomo-Hernandez

Yendry Ventura-Carmenate

Rene Antonio Rivero-Jimenez

Version 1 : Received: 29 December 2023 / Approved: 3 January 2024 / Online: 3 January 2024 (10:37:27 CET)

A peer-reviewed article of this Preprint also exists.

Sotomayor-Lugo, F.; Iglesias-Barrameda, N.; Castillo-Aleman, Y.M.; Casado-Hernandez, I.; Villegas-Valverde, C.A.; Bencomo-Hernandez, A.A.; Ventura-Carmenate, Y.; Rivero-Jimenez, R.A. The Dynamics of Histone Modifications during Mammalian Zygotic Genome Activation. Int. J. Mol. Sci. 2024, 25, 1459. Sotomayor-Lugo, F.; Iglesias-Barrameda, N.; Castillo-Aleman, Y.M.; Casado-Hernandez, I.; Villegas-Valverde, C.A.; Bencomo-Hernandez, A.A.; Ventura-Carmenate, Y.; Rivero-Jimenez, R.A. The Dynamics of Histone Modifications during Mammalian Zygotic Genome Activation. Int. J. Mol. Sci. 2024, 25, 1459.

Abstract

Mammalian fertilization initiates the reprogramming of oocytes and sperm, leading to the formation of a totipotent zygote. The zygotic genome remains transcriptionally silent throughout this intricate process, undergoing the maternal-to-zygotic transition (MZT) and subsequent zygotic genome activation (ZGA). Histone modifications are pivotal in shaping cellular identity and gene expression in many mammals. Recent advances in chromatin analysis enable a detailed exploration of histone modifications during ZGA. This review delves into conserved and unique regulatory strategies, providing essential insights into the dynamic changes in histone modifications and their variants during ZGA in mammals. The objective is to explore recent advancements in leading mechanisms related to histone modifications governing this embryonic development phase in depth. These considerations will be useful for informing future therapeutic approaches that target epigenetic regulation in diverse biological contexts, ranging from regenerative medicine to cancer research. It will also contribute to the extensive areas of evolutionary and developmental biology and possibly lay the foundation for future research and discussion on this seminal topic.

Keywords

histone modifications; chromatin landscape; mammals; embryonic development; embryonic stem cells

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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