Review
Version 1
Preserved in Portico This version is not peer-reviewed
Recent Advances in Real-time Label-Free Detection of Small Molecules
Version 1
: Received: 1 January 2024 / Approved: 2 January 2024 / Online: 3 January 2024 (02:34:43 CET)
A peer-reviewed article of this Preprint also exists.
Chieng, A.; Wan, Z.; Wang, S. Recent Advances in Real-Time Label-Free Detection of Small Molecules. Biosensors 2024, 14, 80. Chieng, A.; Wan, Z.; Wang, S. Recent Advances in Real-Time Label-Free Detection of Small Molecules. Biosensors 2024, 14, 80.
Abstract
The detection and analysis of small molecules, typically defined as molecules under 1000 Da, is of growing interest ranging from the development of small molecule drugs and inhibitors to the sensing of toxins and biomarkers. However, due to challenges such as their small size and low mass, many biosensing technologies struggle to have the sensitivity and selectivity for the detection of small molecules. Notably, their small size limits the usage of labeled techniques that can change the properties of small molecule analytes. Furthermore, the capability of real-time detection is highly desired for small molecule biosensors’ application in diagnostics or screening. This review highlights recent advances in label-free real-time biosensing technologies utilizing different types of transducers to meet the growing demand for small molecule detection.
Keywords
small molecule; label-free; real-time detection; biosensor; optical transduction; electrochemical transduction; piezoelectric transduction
Subject
Chemistry and Materials Science, Analytical Chemistry
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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