Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Reconstructive Approach in Residual Periodontal Pockets with Biofunctionalized Heterografts – a Retrospective Comparison of 12-Months Data from Three Centers

Anton Friedmann
* ORCID logo ,
Pheline Liedloff
,
Meizi Eliezer
,
Arthur Brincat
,
Thomas Ostermann
ORCID logo ,
Daniel Diehl
ORCID logo
Version 1 : Received: 30 December 2023 / Approved: 30 December 2023 / Online: 3 January 2024 (03:56:06 CET)

A peer-reviewed article of this Preprint also exists.

Friedmann, A.; Liedloff, P.; Eliezer, M.; Brincat, A.; Ostermann, T.; Diehl, D. Reconstructive Approach in Residual Periodontal Pockets with Biofunctionalized Heterografts—A Retrospective Comparison of 12-Month Data from Three Centers. J. Funct. Biomater. 2024, 15, 39. Friedmann, A.; Liedloff, P.; Eliezer, M.; Brincat, A.; Ostermann, T.; Diehl, D. Reconstructive Approach in Residual Periodontal Pockets with Biofunctionalized Heterografts—A Retrospective Comparison of 12-Month Data from Three Centers. J. Funct. Biomater. 2024, 15, 39.

Abstract

Regenerative capacity of well-preserved blood clot may be enhanced by biologics like enamel matrix derivative (EMD). This retrospective analysis compares outcomes reported by three centers using different heterografts. Center 1 (C1) treated intrabony defects combining cross-linked heavy weight hyaluronic acid (xHyA) with a xenograft, Center 2 (C2) used EMD with an allograft combination to graft residual pocket. Center 3 (C3) combined xHyA with placement of resorbable polymer membrane for defect cover. Clinical parameters, BoP reduction and radiographically observed defect fill at 12-months examination are reported. The 12-months evaluation yielded significant improvement in PPD and CAL at each center (p<0.001, respectively). Analyses of Covariance revealed significant improvement of all parameters, significantly greater CAL gain disclosed C2 vs. C1 (p=0.006). Radiographic defect fill presented with significantly higher scores for C2 and C3 vs. C1 (P=.003 and =.014; C2 vs. C3 P=1.00). Gingival recession increased in C1 and C3 (P=1.00), while C2 reported no GR after 12-months (C2:C1 P=.002; C2:C3 P=.005). BoP tendency and pocket closure rate shared similar rates. Within limitations of the study, data comparison indicated that xHyA showed similar capacity to enhance regenerative response, as known for EMD. Radiographic follow-up underlined xHyA staying alone role in new attachment formation.

Keywords

Heterograft; EMD; xHyA; synthetic polymer barrier; bovine xenograft with Hydroxyapatite; allograft

Subject

Medicine and Pharmacology, Dentistry and Oral Surgery

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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