Version 1
: Received: 29 December 2023 / Approved: 30 December 2023 / Online: 30 December 2023 (15:35:27 CET)
How to cite:
Kufner, A.C.; Zink, S.; Wohlgemuth, K. Speeding-Up Process Development of Continuous Slug Flow Crystallization for Novel Substance Systems. Preprints2023, 2023122336. https://doi.org/10.20944/preprints202312.2336.v1
Kufner, A.C.; Zink, S.; Wohlgemuth, K. Speeding-Up Process Development of Continuous Slug Flow Crystallization for Novel Substance Systems. Preprints 2023, 2023122336. https://doi.org/10.20944/preprints202312.2336.v1
Kufner, A.C.; Zink, S.; Wohlgemuth, K. Speeding-Up Process Development of Continuous Slug Flow Crystallization for Novel Substance Systems. Preprints2023, 2023122336. https://doi.org/10.20944/preprints202312.2336.v1
APA Style
Kufner, A.C., Zink, S., & Wohlgemuth, K. (2023). Speeding-Up Process Development of Continuous Slug Flow Crystallization for Novel Substance Systems. Preprints. https://doi.org/10.20944/preprints202312.2336.v1
Chicago/Turabian Style
Kufner, A.C., Sarina Zink and Kerstin Wohlgemuth. 2023 "Speeding-Up Process Development of Continuous Slug Flow Crystallization for Novel Substance Systems" Preprints. https://doi.org/10.20944/preprints202312.2336.v1
Abstract
The pharmaceutical industry is undergoing a shift in processing methods for small-scale production (250-1000 kg/a), leading to an increased focus on continuous production research. Various concepts were developed to overcome challenges in small-scale crystallization for the production of high-quality products. However, further optimization is needed to enhance the industrial applicability of these concepts. This study aims to demonstrate the practical applicability of the Slug Flow Crystallizer (SFC) in the pharmaceutical industry by extending its use to a wider range of substance systems for small-scale API production. Employing an experimental strategy, the research seeks to rapidly assess the SFC's potential for achieving uniform, high-purity product yields, emphasizing the importance of factors such as slug flow stability, residence time distribution, and substance-specific crystallization criteria. This, coupled with our previously published model-based strategy, forms a comprehensive methodology to explore crystallization behavior and modeling for a variety of substance systems within the SFC. The ultimate goal of this study is to showcase the practicality of the SFC in the pharmaceutical industry, enabling the way for its reliable use in long-term, small-scale continuous crystallization and the production of high-quality pharmaceutical products.
Engineering, Industrial and Manufacturing Engineering
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
