Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Neuroprotective Effect of Therapeutic Hypothermia in Cognitive Impairment of tMCAo Mouse Model

Ji Sun Lim
,
Shin Kim
,
Mee-Na Park
,
Hyunsu Lee
ORCID logo ,
Hye Suk Baek
,
Jin Kyung Kim
,
Hae Won Kim
* ,
Jeong-Ho Hong
* ORCID logo
Version 1 : Received: 29 December 2023 / Approved: 29 December 2023 / Online: 29 December 2023 (13:35:09 CET)

A peer-reviewed article of this Preprint also exists.

Lim, J.S.; Kim, S.; Park, M.-N.; Lee, H.; Baek, H.S.; Kim, J.K.; Kim, H.W.; Hong, J.-H. The Neuroprotective Effect of Therapeutic Hypothermia in Cognitive Impairment of an Ischemia/Reperfusion Injury Mouse Model. Medicina 2024, 60, 350. Lim, J.S.; Kim, S.; Park, M.-N.; Lee, H.; Baek, H.S.; Kim, J.K.; Kim, H.W.; Hong, J.-H. The Neuroprotective Effect of Therapeutic Hypothermia in Cognitive Impairment of an Ischemia/Reperfusion Injury Mouse Model. Medicina 2024, 60, 350.

Abstract

Therapeutic hypothermia (TH) has emerged as a promising approach with neuroprotective effects that can mitigate secondary brain damage and intracranial pressure in the acute phase after successful mechanical thrombectomy. However, the effect of TH on cognitive impairment has yet fully elucidated. In the present study, we demonstrated whether TH can improve cognitive impairment in a transient middle cerebral artery occlusion (tMCAO) mouse model Nine-week-old C57BL/6N mice (male) were randomized to three groups: sham, tMCAO, and tMCAO with TH. One month after model induction, cognitive function test and regional cerebral glucose metabolism were evaluated using the Y-maze test and positron emission tomography with fluorine-18 fluorodeoxyglucose, respectively. tMCAO led to cognitive impairment, which was improved by TH. The cerebral glucose metabolism of the thalamus was significantly recovered in the TH group compared to that in the tMCAO group. These results suggest that TH might have potential as a therapeutic strategy for improving the ischemia/reperfusion-induced cognitive impairment.

Keywords

Ischemic stroke, Hypothermia, Cognition, Neuroprotection

Subject

Biology and Life Sciences, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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