Acetamiprid Exposure-Induces Molecular and Structural Changes in Liver and Kidney Tissues of Rats

Annu Phogat; Jagjeet Singh; Reena Sheoran; Arun Hasanpuri; Vijay Singh; Vijay Kumar; Chandra Prakash; Vinay Malik

doi:10.20944/preprints202312.2173.v1

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preprints.org > biology and life sciences > biochemistry and molecular biology > doi: 10.20944/preprints202312.2173.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Acetamiprid Exposure-Induces Molecular and Structural Changes in Liver and Kidney Tissues of Rats

Version 1 : Received: 27 December 2023 / Approved: 28 December 2023 / Online: 28 December 2023 (14:51:51 CET)

How to cite: Phogat, A.; Singh, J.; Sheoran, R.; Hasanpuri, A.; Singh, V.; Kumar, V.; Prakash, C.; Malik, V. Acetamiprid Exposure-Induces Molecular and Structural Changes in Liver and Kidney Tissues of Rats. Preprints 2023, 2023122173. https://doi.org/10.20944/preprints202312.2173.v1 Phogat, A.; Singh, J.; Sheoran, R.; Hasanpuri, A.; Singh, V.; Kumar, V.; Prakash, C.; Malik, V. Acetamiprid Exposure-Induces Molecular and Structural Changes in Liver and Kidney Tissues of Rats. Preprints 2023, 2023122173. https://doi.org/10.20944/preprints202312.2173.v1

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MDPI and ACS Style

Phogat, A.; Singh, J.; Sheoran, R.; Hasanpuri, A.; Singh, V.; Kumar, V.; Prakash, C.; Malik, V. Acetamiprid Exposure-Induces Molecular and Structural Changes in Liver and Kidney Tissues of Rats. Preprints 2023, 2023122173. https://doi.org/10.20944/preprints202312.2173.v1

APA Style

Phogat, A., Singh, J., Sheoran, R., Hasanpuri, A., Singh, V., Kumar, V., Prakash, C., & Malik, V. (2023). Acetamiprid Exposure-Induces Molecular and Structural Changes in Liver and Kidney Tissues of Rats. Preprints. https://doi.org/10.20944/preprints202312.2173.v1

Chicago/Turabian Style

Phogat, A., Chandra Prakash and Vinay Malik. 2023 "Acetamiprid Exposure-Induces Molecular and Structural Changes in Liver and Kidney Tissues of Rats" Preprints. https://doi.org/10.20944/preprints202312.2173.v1

Abstract

Pesticides are among the most widely used synthetic chemicals worldwide to protect crops, but besides being beneficial, they pose several environmental and health issues. The present study evaluates toxic effects of acetamiprid (ACMP) in rat liver and kidney tissues. Rats were exposed to ACMP (21.7 mg/kg b.wt; 1/10th LD50) for 21 days. Oxidative stress generation, apoptotic progression, and structural changes were evaluated via biochemical assays, semi-quantitative PCR, western blotting, and histopathology. ACMP exposure significantly decreased body weight and altered relative organ weight in hepato-renal tissues. Significant oxidative stress was evident by increased oxidative injuries to lipids and proteins and alterations of endogenous anti-oxidative enzymes. The administration of ACMP upregulated mRNA expression of Bax and caspase-3, while downregulated the mRNA expression of Bcl-2 and released cytochrome c into the cytosol of the liver and kidney tissues. Likewise, exposure to ACMP caused severe degenerative changes in the histo-architecture of hepato-renal tissues. The results of the present study confirmed the toxicity of ACMP in rats’ liver and kidney tissues and emphasized the need for strict regulation and more mechanistic understanding to delineate the toxicity of ACMP in mammals.

Keywords

Acetamiprid; apoptosis; toxicity; histopathology; oxidative stress

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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