Cruz-Maya, I.; Schiavone, C.; Ferraro, R.; Renkler, N.Z.; Caserta, S.; Guarino, V. Designing Advanced Drug Delivery Systems: Core-Shell Alginate Particles through Electro-Fluid Dynamic Atomization. Pharmaceutics2024, 16, 193.
Cruz-Maya, I.; Schiavone, C.; Ferraro, R.; Renkler, N.Z.; Caserta, S.; Guarino, V. Designing Advanced Drug Delivery Systems: Core-Shell Alginate Particles through Electro-Fluid Dynamic Atomization. Pharmaceutics 2024, 16, 193.
Cruz-Maya, I.; Schiavone, C.; Ferraro, R.; Renkler, N.Z.; Caserta, S.; Guarino, V. Designing Advanced Drug Delivery Systems: Core-Shell Alginate Particles through Electro-Fluid Dynamic Atomization. Pharmaceutics2024, 16, 193.
Cruz-Maya, I.; Schiavone, C.; Ferraro, R.; Renkler, N.Z.; Caserta, S.; Guarino, V. Designing Advanced Drug Delivery Systems: Core-Shell Alginate Particles through Electro-Fluid Dynamic Atomization. Pharmaceutics 2024, 16, 193.
Abstract
Innovations in drug delivery systems are crucial for enhancing therapeutic efficiency. Our research presents a novel approach based on Electro-fluid dynamic atomization (EFDA) to fabricate core-shell monophasic particles (CSMp) from sodium alginate blends of varying molecular weights. This study explores the morphological characteristics of these particles in relation to material properties and process conditions, highlighting their potential in drug delivery applications. A key aspect of our work is the development of a mathematical model that simulates the release kinetics of small molecules, specifically sodium diclofenac. By assessing the diffusion properties of different molecules and gel formulations through transport and rheological models, we have created a predictive tool for evaluating the efficiency of these particles in drug delivery. Our findings underscore two critical independent parameters for optimizing drug release: the external shell thickness and the diffusivity ratios within the dual layers. This allows for precise control over the timing and intensity of the release profile. The study advances our understanding of EFDA in the fabrication of CSMp and offers promising avenues for enhancing drug delivery systems by tailoring release profiles through particle characteristic manipulation.
Chemistry and Materials Science, Materials Science and Technology
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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