Version 1
: Received: 26 December 2023 / Approved: 26 December 2023 / Online: 26 December 2023 (14:36:38 CET)
Version 2
: Received: 27 December 2023 / Approved: 27 December 2023 / Online: 27 December 2023 (14:28:59 CET)
Gordeeva, D.S.; Sitenkova (Bukhovets), A.V.; Moustafine, R.I. New Carriers for Bioadhesive Gastroretentive Drug Delivery Systems Based on Eudragit® EPO/Eudragit® L100 Interpolyelectrolyte Complexes. Sci. Pharm.2024, 92, 14.
Gordeeva, D.S.; Sitenkova (Bukhovets), A.V.; Moustafine, R.I. New Carriers for Bioadhesive Gastroretentive Drug Delivery Systems Based on Eudragit® EPO/Eudragit® L100 Interpolyelectrolyte Complexes. Sci. Pharm. 2024, 92, 14.
Gordeeva, D.S.; Sitenkova (Bukhovets), A.V.; Moustafine, R.I. New Carriers for Bioadhesive Gastroretentive Drug Delivery Systems Based on Eudragit® EPO/Eudragit® L100 Interpolyelectrolyte Complexes. Sci. Pharm.2024, 92, 14.
Gordeeva, D.S.; Sitenkova (Bukhovets), A.V.; Moustafine, R.I. New Carriers for Bioadhesive Gastroretentive Drug Delivery Systems Based on Eudragit® EPO/Eudragit® L100 Interpolyelectrolyte Complexes. Sci. Pharm. 2024, 92, 14.
Abstract
Interpolyelectrolyte complexes Eudragit® EPO/L100 received in different pH were characterized by different degree of swelling in mimicking fasted stomach medium (0.1 M HCl) and saved their shape during 6 hours of the experiment. The microenvironmental changes in IPECs structure during swelling testing were inves-tigated using FT-IR spectroscopy, thermal and elemental analysis. Both samples of IPECs during swelling were transformed to a similar structure with approximately the same composition. IPEC samples showed bioadhesive properties that was not significantly different from the positive control (Carbopol) in the test with the mucin compacts. The release rate of metronidazole (class I BCS) from IPEC matrices increased with the increasing degree of swelling. IPEC 1 provided 49.62 ± 6.20% and IPEC 2 – 87.69 ± 5.15 % of metronidazole release after 6 hours in mimicking fasted stomach medium (0.1 M HCl). Total amount of released acyclovir (class III BCS) from IPEC 1 was 25.76 ± 5.67 % and from IPEC 2 was 21.48 ± 5.00 %. Release of both drugs was controlled by relaxation of polymeric chains in matrices according to the Peppas-Sahlin model. According to the received results, investigated interpolymer complexes are perspective for further evalua-tion as carriers for gastroretentive bioadhesive systems.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received:
27 December 2023
Commenter:
Rouslan Moustafine
Commenter's Conflict of Interests:
Author
Comment:
Dear Dr. Moustafine,
Your paper has been assigned to Xiaoshan Wan, who will be your main point of contact as your paper is processed further.
Journal: Scientia Pharmaceutica Manuscript ID: scipharm-2805191 Title: New carriers for bioadhesive gastroretentive drug delivery systems based on Eudragit® EPO/Eudragit® L100 interpolyelectrolyte complexes Authors: Daria S Gordeeva, Aleksandra V Sitenkova, Rouslan I. Moustafine * Received: 18 Dec 2023 E-mails: daria.gordeeva@kazangmu.ru, aleksandra.sitenkova@kazangmu.ru, ruslan.mustafin@kazangmu.ru
You can find your paper here: https://susy.mdpi.com/user/manuscripts/review_info/49b4f124e369ecf4221d0eb6ed3f0a43
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Best regards, Xiaoshan Wan, Ph.D. Section Managing Editor E-Mail:xiaoshan.wan@mdpi.com
Commenter: Rouslan Moustafine
Commenter's Conflict of Interests: Author
Your paper has been assigned to Xiaoshan Wan, who will be your main point of
contact as your paper is processed further.
Journal: Scientia Pharmaceutica
Manuscript ID: scipharm-2805191
Title: New carriers for bioadhesive gastroretentive drug delivery systems
based on Eudragit® EPO/Eudragit® L100 interpolyelectrolyte complexes
Authors: Daria S Gordeeva, Aleksandra V Sitenkova, Rouslan I. Moustafine *
Received: 18 Dec 2023
E-mails: daria.gordeeva@kazangmu.ru, aleksandra.sitenkova@kazangmu.ru,
ruslan.mustafin@kazangmu.ru
You can find your paper here:
https://susy.mdpi.com/user/manuscripts/review_info/49b4f124e369ecf4221d0eb6ed3f0a43
Manuscripts must be written in good English. Incorrect English can result in
rejection if reviewers cannot understand your work. If extensive English
editing is required, your manuscript could also be returned to you, which
will delay its publication. MDPI offers rapid English editing, completed in 1
day: Author Services (https://www.mdpi.com/authors/english)
Please note that emails requesting any payment or collaboration with MDPI
will be sent exclusively from an “@mdpi.com” address. If you receive an
email from someone posing as MDPI not sent from an “@mdpi.com“ address,
please alert us as soon as possible.
More information can be found here:
https://www.mdpi.com/authors/avoid-phishing-emails
If you have any questions, please contact me in advance.
Best regards,
Xiaoshan Wan, Ph.D.
Section Managing Editor
E-Mail: xiaoshan.wan@mdpi.com
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