The Dynamic Crosstalk between Gut Microbiota, Immune System, and Autophagy in the Onset of Inflammatory Bowel Disease: Molecular Mechanisms and Current Therapeutic Approaches

Beatrice Garavaglia; Letizia Vallino; Angela Amoruso; Marco Pane; Alessandra Ferraresi; Ciro Isidoro

doi:10.20944/preprints202312.1804.v1

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preprints.org > biology and life sciences > immunology and microbiology > doi: 10.20944/preprints202312.1804.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Dynamic Crosstalk between Gut Microbiota, Immune System, and Autophagy in the Onset of Inflammatory Bowel Disease: Molecular Mechanisms and Current Therapeutic Approaches

Version 1 : Received: 24 December 2023 / Approved: 25 December 2023 / Online: 26 December 2023 (01:46:56 CET)

How to cite: Garavaglia, B.; Vallino, L.; Amoruso, A.; Pane, M.; Ferraresi, A.; Isidoro, C. The Dynamic Crosstalk between Gut Microbiota, Immune System, and Autophagy in the Onset of Inflammatory Bowel Disease: Molecular Mechanisms and Current Therapeutic Approaches. Preprints 2023, 2023121804. https://doi.org/10.20944/preprints202312.1804.v1 Garavaglia, B.; Vallino, L.; Amoruso, A.; Pane, M.; Ferraresi, A.; Isidoro, C. The Dynamic Crosstalk between Gut Microbiota, Immune System, and Autophagy in the Onset of Inflammatory Bowel Disease: Molecular Mechanisms and Current Therapeutic Approaches. Preprints 2023, 2023121804. https://doi.org/10.20944/preprints202312.1804.v1

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MDPI and ACS Style

Garavaglia, B.; Vallino, L.; Amoruso, A.; Pane, M.; Ferraresi, A.; Isidoro, C. The Dynamic Crosstalk between Gut Microbiota, Immune System, and Autophagy in the Onset of Inflammatory Bowel Disease: Molecular Mechanisms and Current Therapeutic Approaches. Preprints 2023, 2023121804. https://doi.org/10.20944/preprints202312.1804.v1

APA Style

Garavaglia, B., Vallino, L., Amoruso, A., Pane, M., Ferraresi, A., & Isidoro, C. (2023). The Dynamic Crosstalk between Gut Microbiota, Immune System, and Autophagy in the Onset of Inflammatory Bowel Disease: Molecular Mechanisms and Current Therapeutic Approaches. Preprints. https://doi.org/10.20944/preprints202312.1804.v1

Chicago/Turabian Style

Garavaglia, B., Alessandra Ferraresi and Ciro Isidoro. 2023 "The Dynamic Crosstalk between Gut Microbiota, Immune System, and Autophagy in the Onset of Inflammatory Bowel Disease: Molecular Mechanisms and Current Therapeutic Approaches" Preprints. https://doi.org/10.20944/preprints202312.1804.v1

Abstract

The crosstalk between gut microbiota, intestinal epithelial cells, and innate and adaptive immune system governs the maintenance of the intestinal homeostasis. Any interference in this tight dialogue and in the processes preserving cellular homeostasis (e.g., autophagy) may dysregulate the immune response and impair the clearance of harmful bacteria favoring the dysbiotic alteration of the microbic flora that leads to chronic inflammation. Gut dysbiosis is strongly associated with gastrointestinal inflammatory disorders, among them the inflammatory bowel disease (IBD). This review discusses the current knowledge on IBD, from the genetic background of high-risk patients to the molecular mechanisms underlying the disease, the contribution of the microbic flora, and the role of autophagy in intestinal epithelial cells and provides the state of art regarding the targeted-nutritional approaches aimed to restore the beneficial crosstalk between an “anti-inflammatory” microbiota and the host. Analysis of the molecular pathogenesis of IBD will help identify genetic and diet-associated risk factors and thus suggest personalized strategies to prevent and manage the disease to improve quality of life with long-term maintenance of the remission phase.

Keywords

IBD; Crohn's disease; ulcerative colitis; inflammation; immune system; autophagy; microbiota; probiotics; fecal microbiota transplantation

Subject

Biology and Life Sciences, Immunology and Microbiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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