Version 1
: Received: 21 December 2023 / Approved: 22 December 2023 / Online: 22 December 2023 (10:14:17 CET)
How to cite:
Datta, N. Unravelling the Intricacies of Telomere Replication: A Molecular Conundrum. Preprints2023, 2023121720. https://doi.org/10.20944/preprints202312.1720.v1
Datta, N. Unravelling the Intricacies of Telomere Replication: A Molecular Conundrum. Preprints 2023, 2023121720. https://doi.org/10.20944/preprints202312.1720.v1
Datta, N. Unravelling the Intricacies of Telomere Replication: A Molecular Conundrum. Preprints2023, 2023121720. https://doi.org/10.20944/preprints202312.1720.v1
APA Style
Datta, N. (2023). Unravelling the Intricacies of Telomere Replication: A Molecular Conundrum. Preprints. https://doi.org/10.20944/preprints202312.1720.v1
Chicago/Turabian Style
Datta, N. 2023 "Unravelling the Intricacies of Telomere Replication: A Molecular Conundrum" Preprints. https://doi.org/10.20944/preprints202312.1720.v1
Abstract
Telomeres are specialized structures at the ends of linear chromosomes that protect them from degradation and fusion. Telomere replication is a complex process that involves both DNA polymerases and a specialized enzyme called telomerase. Telomerase is a ribonucleoprotein complex that synthesizes telomeric DNA by using an internal RNA template. However, telomerase alone cannot fully replicate the telomeric DNA, and requires the cooperation of other factors, such as shelterin, CST, and DNA repair proteins. Moreover, telomere replication is tightly regulated by various mechanisms, such as cell cycle checkpoints, telomere length homeostasis, and telomere position effect. Dysregulation of telomere replication can lead to genomic instability, cellular senescence, and cancer. Therefore, understanding the molecular details of telomere replication is crucial for elucidating the role of telomeres in aging and disease.
Keywords
telomere; DNA replication; chromosome; shelterin; molecular biology
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
