Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

A Comprehensive Review on the Role of Resting State Functional Magnetic Resonance Imaging in Predicting Post-stroke Motor and Sensory Outcome

Foteini Christidi
,
Ilias Orgianelis
,
Ermis Merkouris
ORCID logo ,
Christos Koutsokostas
,
Dimitrios Tsiptsios
* ORCID logo ,
Efstratios Karavasilis
,
Evlampia A. Psatha
,
Anna Tsiakiri
ORCID logo ,
Aspasia Serdari
,
Nikolaos Aggelousis
ORCID logo ,
Konstantinos Vadikolias
ORCID logo
Version 1 : Received: 20 December 2023 / Approved: 20 December 2023 / Online: 20 December 2023 (21:49:18 CET)

A peer-reviewed article of this Preprint also exists.

Christidi, F.; Orgianelis, I.; Merkouris, E.; Koutsokostas, C.; Tsiptsios, D.; Karavasilis, E.; Psatha, E.A.; Tsiakiri, A.; Serdari, A.; Aggelousis, N.; Vadikolias, K. A Comprehensive Review on the Role of Resting-State Functional Magnetic Resonance Imaging in Predicting Post-Stroke Motor and Sensory Outcomes. Neurol. Int. 2024, 16, 189-201. Christidi, F.; Orgianelis, I.; Merkouris, E.; Koutsokostas, C.; Tsiptsios, D.; Karavasilis, E.; Psatha, E.A.; Tsiakiri, A.; Serdari, A.; Aggelousis, N.; Vadikolias, K. A Comprehensive Review on the Role of Resting-State Functional Magnetic Resonance Imaging in Predicting Post-Stroke Motor and Sensory Outcomes. Neurol. Int. 2024, 16, 189-201.

Abstract

Stroke is a major leading cause of chronic disability, often affecting patients’ motor and sensory functions. Functional magnetic resonance imaging (fMRI) is the most commonly used method of functional neuroimaging and allows the non-invasive study of brain activity. The time-dependent coactivation of different brain regions at rest is described as resting-state activation. As a non-invasive task-independent functional neuroimaging approach, resting-state fMRI (rs-fMRI) may provide therapeutically useful information on both the focal vascular lesion and the connectivity-based reorganization and subsequent functional recovery in stroke patients. Considering the role of prompt and accurate prognosis in stroke survivors along with the potential of rs-fMRI in identifying patterns of neuroplasticity in different post-stroke phases, this review provides a comprehensive overview of the latest literature regarding the role of rs-fMRI in stroke prognosis in terms of motor and sensory outcome. Our comprehensive review suggests that with the advancement of MRI acquisition and data analysis methods, rs-fMRI emerges as a promising tool to study the motor and sensory outcome in stroke patients and evaluate the effect of different interventions.

Keywords

functional magnetic resonance imaging; resting-state functional connectivity; stroke; motor outcome; sensory outcome; biomarkers

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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