Marinova, P.E.; Tamahkyarova, K.D. Synthesis and Biological Activities of Some Metal Complexes of 2-Thiouracil and Its Derivatives: A Review. Compounds2024, 4, 186-213.
Marinova, P.E.; Tamahkyarova, K.D. Synthesis and Biological Activities of Some Metal Complexes of 2-Thiouracil and Its Derivatives: A Review. Compounds 2024, 4, 186-213.
Marinova, P.E.; Tamahkyarova, K.D. Synthesis and Biological Activities of Some Metal Complexes of 2-Thiouracil and Its Derivatives: A Review. Compounds2024, 4, 186-213.
Marinova, P.E.; Tamahkyarova, K.D. Synthesis and Biological Activities of Some Metal Complexes of 2-Thiouracil and Its Derivatives: A Review. Compounds 2024, 4, 186-213.
Abstract
The thionamide antithyroid drugs were discovered largely following serendipitous observations by numerous researchers in the 1940s who found that sulfhydryl-containing compounds were goitrogenic in animals. Prof. Edwin B. Astwood was the first to use these compounds to treat hyperthyroidism. In this review, we summarize the history of the development of these drugs and the coordination possibility of 2-thiouracil and its derivatives, as well as the biological activities of some of its complexes. Some of them are used as agents for the treatment of tuberculosis, and arthritis, others have bactericidal and fungicidal activity, the third cytotoxic properties, and could be used to treat various types of cancer.
Chemistry and Materials Science, Inorganic and Nuclear Chemistry
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