Review
Version 1
Preserved in Portico This version is not peer-reviewed
Contact Inhibition and Mechanotransduction
Version 1
: Received: 19 December 2023 / Approved: 19 December 2023 / Online: 19 December 2023 (11:43:53 CET)
A peer-reviewed article of this Preprint also exists.
Nakamura, F. The Role of Mechanotransduction in Contact Inhibition of Locomotion and Proliferation. Int. J. Mol. Sci. 2024, 25, 2135. Nakamura, F. The Role of Mechanotransduction in Contact Inhibition of Locomotion and Proliferation. Int. J. Mol. Sci. 2024, 25, 2135.
Abstract
Contact inhibition (CI) represents a crucial tumor-suppressive mechanism responsible for controlling the unbridled growth of cells, thus preventing the formation of cancerous tissues. CI can be further categorized into two distinct yet interrelated components: CI of locomotion (CIL) and CI of proliferation (CIP). These two components of CI have historically been viewed as separate processes, but emerging research indicates that they share both distinctive and common pathways. Moreover, they exhibit intriguing intersections with mechanotransduction, a process that involves cells sensing and responding to mechanical forces. This review article describes the intricate interplay between mechanical forces and CI, shedding light on how these forces regulate CIL and CIP. Emphasis is placed on filamin A (FLNA)-mediated mechanotransduction, elucidating how FLNA senses mechanical forces and translates them into crucial biochemical signals that regulate cell locomotion and proliferation. In addition to FLNA, trans-acting factors (TAFs) emerge as sensitive players in both CI and the mechanotransduction process. This article presents methods for identifying these TAFs and profiling the associated changes in chromatin structure, offering valuable insights into CI and mechanotransduction regulation. Finally, it addresses unanswered research questions in these fields and delineates their possible future directions.
Keywords
contact inhibition; contact inhibition of locomotion; contact inhibition of proliferation; mechanotransduction; filamin; mechanical force; YAP; gene expression; proteomics
Subject
Biology and Life Sciences, Cell and Developmental Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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