Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Pharmacokinetics of Tilmicosin in Plasma, Urine and Feces after a Single Intragastric Administration in Donkey (Equus asinus)

Bowen Yang
ORCID logo ,
Shijie Liu
,
Yanxin Guo
,
Honglei Qu
,
Yulong Feng
,
Yantao Wang
,
Boying Dong
,
Yanjie Dong
,
Shancang Zhao
,
Shimeng Huang
,
Lihong Zhao
ORCID logo ,
Jianyun Zhang
,
Cheng Ji
,
Qiugang Ma
* ORCID logo
Version 1 : Received: 18 December 2023 / Approved: 18 December 2023 / Online: 18 December 2023 (10:52:55 CET)

A peer-reviewed article of this Preprint also exists.

Yang, B.; Liu, S.; Guo, Y.; Qu, H.; Feng, Y.; Wang, Y.; Dong, B.; Dong, Y.; Zhao, S.; Huang, S.; et al. Pharmacokinetics of Tilmicosin in Plasma, Urine and Feces after a Single Intragastric Administration in Donkey (Equus Asinus). Journal of Veterinary Pharmacology and Therapeutics 2024, doi:10.1111/jvp.13446. Yang, B.; Liu, S.; Guo, Y.; Qu, H.; Feng, Y.; Wang, Y.; Dong, B.; Dong, Y.; Zhao, S.; Huang, S.; et al. Pharmacokinetics of Tilmicosin in Plasma, Urine and Feces after a Single Intragastric Administration in Donkey (Equus Asinus). Journal of Veterinary Pharmacology and Therapeutics 2024, doi:10.1111/jvp.13446.

Abstract

Background: Tilmicosin, a macrolide antibiotic, has the potential to treat bacterial respiratory infections in donkeys. However, the pharmacokinetics of tilmicosin in donkeys have not been reported. Objectives: The aim of this study was to investigate the pharmacokinetics of tilmicosin in donkey plasma, urine and feces after a single intragastric administration to determine the suitability of tilmicosin for donkeys. Animals: A total of 4 healthy fattening male donkeys were selected with body weights of 148, 140, 145, and 135 kg, with an average body weight of 142.00 ± 4.95 kg. Methods: The donkeys were administered intragastrically a single dose of 10 mg·kg-1 BW tilmicosin. Blood, urine and fecal samples were collected. The concentrations of tilmicosin in plasma, urine, and feces were determined using high-performance liquid chromatography-tandem masss pectrometry. Results: After a single intragastric administration of 10 mg·kg-1 body weight, tilmicosin in donkey plasma reached a maximum concentration of 11.23 ± 5.97 mg·L-1 at 0.81 ± 0.11 h, with a mean residence time of 8.05 ± 2.44 h, a Cl/F of 0.48±0.22 L·kg-1·h-1, and a Vd/F of 9.28 ± 4.10 L·kg-1. The percentage of tilmicosin excreted through the urine of donkeys is (2.47±0.43)%, and the percentage excreted through the feces is (66.43±8.65)%. Conclusions: A single intragastric administration of 10 mg·kg-1 BW of tilmicosin to donkeys was rapidly absorbed and was able to achieve plasma concentrations of against pathogenic bacteria.

Keywords

tilmicosin; pharmacokinetics; intragastric administration; excretion; donkey

Subject

Medicine and Pharmacology, Veterinary Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.