Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Mast Cells in Cardiac Remodeling: Focus on the Right Ventricle

Argen Mamazhakypov
ORCID logo ,
Abdirashit Maripov
,
Akpay S. Sarybaev
,
Ralph Theo Schermuly
ORCID logo ,
Akylbek Sydykov
* ORCID logo
Version 1 : Received: 15 December 2023 / Approved: 18 December 2023 / Online: 18 December 2023 (13:17:23 CET)

A peer-reviewed article of this Preprint also exists.

Mamazhakypov, A.; Maripov, A.; Sarybaev, A.S.; Schermuly, R.T.; Sydykov, A. Mast Cells in Cardiac Remodeling: Focus on the Right Ventricle. J. Cardiovasc. Dev. Dis. 2024, 11, 54. Mamazhakypov, A.; Maripov, A.; Sarybaev, A.S.; Schermuly, R.T.; Sydykov, A. Mast Cells in Cardiac Remodeling: Focus on the Right Ventricle. J. Cardiovasc. Dev. Dis. 2024, 11, 54.

Abstract

In response to various stressors, cardiac chambers undergo structural remodeling. Long-term exposure of the right ventricle (RV) to pressure or volume overload leads to its maladaptive remodeling, associated with RV failure and increased mortality. While left ventricular adverse remodeling is well understood and therapeutic options are available or emerging, RV remodeling remains underexplored and no specific therapies are currently available. Accumulating evidence implicates a role of mast cells in RV remodeling. Mast cells produce and release numerous inflammatory mediators, growth factors and proteases that can adversely affect cardiac cells, thus contributing to cardiac remodeling. Recent experimental findings suggest that mast cells might represent a potential therapeutic target. This review examines the role of mast cells in cardiac remodeling with specific focus on RV remodeling and explores the potential efficacy of therapeutic interventions targeting mast cells to mitigate adverse RV remodeling.

Keywords

mast cells; right ventricle; cardiac remodeling

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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