Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

A Genome-Wide Association Study for Resistance to Tropical Theileriosis in Two Bovine Portuguese Autochthonous Breeds

Diana Valente
* ORCID logo ,
Octávio Serra
,
Nuno Carolino
,
Jacinto Gomes
ORCID logo ,
Ana Cláudia Coelho
ORCID logo ,
Pedro Espadinha
,
José Pais
,
Inês Carolino
Version 1 : Received: 12 December 2023 / Approved: 13 December 2023 / Online: 13 December 2023 (11:41:48 CET)

A peer-reviewed article of this Preprint also exists.

Valente, D.; Serra, O.; Carolino, N.; Gomes, J.; Coelho, A.C.; Espadinha, P.; Pais, J.; Carolino, I. A Genome-Wide Association Study for Resistance to Tropical Theileriosis in Two Bovine Portuguese Autochthonous Breeds. Pathogens 2024, 13, 71. Valente, D.; Serra, O.; Carolino, N.; Gomes, J.; Coelho, A.C.; Espadinha, P.; Pais, J.; Carolino, I. A Genome-Wide Association Study for Resistance to Tropical Theileriosis in Two Bovine Portuguese Autochthonous Breeds. Pathogens 2024, 13, 71.

Abstract

Control of Tropical Theileriosis, a tick-borne disease with a strong impact on cattle breeding, can be facilitated by using marker-assisted selection in breeding programs. Genome-wide association studies (GWAS) using high-density arrays are extremely important for the ongoing process of identifying genomic variants associated with resistance to Theileria annulata infection. In this work, Single Nucleotide Polymorphisms (SNPs) were analyzed in the Portuguese autochthonous cattle breeds Alentejana and Mertolenga. In total, 14 SNPs suggestive of significance (p ≤ 10-4) were identified for Alentejana cattle and 20 SNPs for Mertolenga cattle. The genomic regions around these SNPs were further investigated for annotated genes and Quantitative trait loci (QTLs) previously described by other authors. Regarding the Alentejana breed, the MAP3K1, CMTM7, SSFA2, and ATG13 genes are located near suggestive SNPs and appear as candidate genes for resistance to Tropical Theileriosis, considering its action the immune response and resistance to other diseases. On the other hand, in the Mertolenga breed, the UOX gene is also a candidate gene due to its apparent link to the pathogenesis of the disease. These results may represent a first step towards the possibility of including genetic markers for resistance to Tropical Theileriosis in current breed selection programs.

Keywords

Genome-Wide Association Studies (GWAS); Theileria annulata; Control of Tropical Theileriosis

Subject

Biology and Life Sciences, Animal Science, Veterinary Science and Zoology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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