Post-irradiation Breast Angiosarcoma: All the Possible Treatments and Electrochemotherapy. Case Report and Literature Review.

Parisi, S.; Gambardella, C.; Iovino, F.; Ruggiero, R.; Lucido, F.S.; Nesta, G.; Tolone, S.; Brusciano, L.; Fisone, F.; Mongardini, F.M.; Cozzolino, G.; Della Corte, C.M.; Napolitano, S.; Orditura, M.; Esposito, R.; Docimo, L. Post-Irradiation Breast Angiosarcoma: All the Possible Treatments and Electrochemotherapy. Case Report and Literature Review. J. Clin. Med. 2024, 13, 567. Parisi, S.; Gambardella, C.; Iovino, F.; Ruggiero, R.; Lucido, F.S.; Nesta, G.; Tolone, S.; Brusciano, L.; Fisone, F.; Mongardini, F.M.; Cozzolino, G.; Della Corte, C.M.; Napolitano, S.; Orditura, M.; Esposito, R.; Docimo, L. Post-Irradiation Breast Angiosarcoma: All the Possible Treatments and Electrochemotherapy. Case Report and Literature Review. J. Clin. Med. 2024, 13, 567.

Abstract

Breast Angiosarcoma is a rare malignancy, accounting less than 1% of all soft tissue. It comprises primitive and secondary subtypes, such as radiogenic breast angiosarcoma (RAS). Despite the multimodal treatment, angiosarcomas represent an incurable disease for many patients and represent a cause of substantial deterioration of their quality of life. Surgery represents the cornerstone in the management, but high recurrence rates are reported. Electrochemotherapy (ECT) is practicable locoregional treatment in patients with advanced angiosarcoma, in a multimodal therapeutic strategy. ECT palliative benefit includes optimal patient compliance, good local hemostasis control, and local responses. Considering that only 22 cases are described in literature, we reported a rare case of RAS treated with ECT, after a multidisciplinary approach including Next Generation Sequencing (NGS). A literature review about the feasibility of ECT in RAS management was also performed.

Keywords

breast angiosarcoma; post-irradiation angiosarcoma; elettrochemotherapy

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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