Review
Version 1
Preserved in Portico This version is not peer-reviewed
The Role of Snake Venom Disintegrins in Angiogenesis
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Version 1
: Received: 11 December 2023 / Approved: 13 December 2023 / Online: 13 December 2023 (03:16:59 CET)
A peer-reviewed article of this Preprint also exists.
Clissa, P.B.; Della-Casa, M.S.; Zychar, B.C.; Sanabani, S.S. The Role of Snake Venom Disintegrins in Angiogenesis. Toxins 2024, 16, 127. Clissa, P.B.; Della-Casa, M.S.; Zychar, B.C.; Sanabani, S.S. The Role of Snake Venom Disintegrins in Angiogenesis. Toxins 2024, 16, 127.
Abstract
Angiogenesis is a critical process in various physiological and pathological conditions, and snake venom disintegrins (SVDs) have been shown to be important regulators of this process. In this review, we explore the dual roles of SVD in angiogenesis, both as antiangiogenic agents by inhibiting integrin binding and interfering with vascular endothelial growth factors and as proangiogenic agents by enhancing integrin binding, stimulating cell migration and proliferation, and inducing neoangiogenesis. Studies in vitro and in animal models have demonstrated these effects and offer significant therapeutic opportunities. The potential applications of SVD in diseases related to angiogenesis, such as cancer, ocular diseases, tissue regeneration, wound healing, and cardiovascular diseases, are also discussed. Overall, SVDs are promising potential therapeutics, and further advances in this field could lead to innovative treatments for diseases related to angiogenesis.
Keywords
snake venom; angiogenesis; integrins; metalloproteinases; disintegrins
Subject
Biology and Life Sciences, Toxicology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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