Version 1
: Received: 12 December 2023 / Approved: 13 December 2023 / Online: 13 December 2023 (11:00:51 CET)
How to cite:
Ye, Z.; Yuan, T. Role and Therapeutic Potential of Non-coding RNAs in Astrocytes during Neonatal Brain Injury. Preprints2023, 2023120927. https://doi.org/10.20944/preprints202312.0927.v1
Ye, Z.; Yuan, T. Role and Therapeutic Potential of Non-coding RNAs in Astrocytes during Neonatal Brain Injury. Preprints 2023, 2023120927. https://doi.org/10.20944/preprints202312.0927.v1
Ye, Z.; Yuan, T. Role and Therapeutic Potential of Non-coding RNAs in Astrocytes during Neonatal Brain Injury. Preprints2023, 2023120927. https://doi.org/10.20944/preprints202312.0927.v1
APA Style
Ye, Z., & Yuan, T. (2023). Role and Therapeutic Potential of Non-coding RNAs in Astrocytes during Neonatal Brain Injury. Preprints. https://doi.org/10.20944/preprints202312.0927.v1
Chicago/Turabian Style
Ye, Z. and Tianming Yuan. 2023 "Role and Therapeutic Potential of Non-coding RNAs in Astrocytes during Neonatal Brain Injury" Preprints. https://doi.org/10.20944/preprints202312.0927.v1
Abstract
Perinatal brain injury is a major public health problem burdened with high morbidity, mortality and severe neurological sequelae. Despite advances in neonatal life-saving technologies, neonatal encephalopathy lacks specific and effective treatment. Therefore, mechanisms of central nervous system changes associated with perinatal brain injury have been a hot topic of neonatology research. In recent years, researchers have shifted more focus from neurons themselves to perineuronal cells and intercellular interactions. As a member of the nervous system network, astrocytes are one of the dominant glial cells that regulate ion homeostasis, blood flow, and antioxidant function in the brain. Their changes in molecular mechanisms (e.g., alterations in RNA regulatory networks) during brain injury storms deserve further attention. Non-coding RNAs participate in and promote reactive pathophysiologic changes in astrocytes. The review summarizes and discusses the role of non-coding RNAs in astrocytes in recent years in studies of neonatal brain injury. It focuses on the most studied disease-related ncRNAs: miRNAs, lncRNAs and circRNAs, and hopes to provide possible directions for pathophysiological studies and therapeutic approaches of neonatal brain injury.
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
