Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Immunohistochemical Expression of the ANGPT1, Casr and PTK2 Proteins in Uterine Fibroids

Anna Markowska
,
Mateusz De Mezer
ORCID logo ,
Paweł Kurzawa
ORCID logo ,
Wiesława Bednarek
,
Anna Gryboś
,
Monika Krzyżaniak
ORCID logo ,
Janina Markowska
,
Marian Gryboś
,
Jakub Żurawski
* ORCID logo
Version 1 : Received: 8 December 2023 / Approved: 8 December 2023 / Online: 11 December 2023 (06:03:40 CET)

How to cite: Markowska, A.; De Mezer, M.; Kurzawa, P.; Bednarek, W.; Gryboś, A.; Krzyżaniak, M.; Markowska, J.; Gryboś, M.; Żurawski, J. Immunohistochemical Expression of the ANGPT1, Casr and PTK2 Proteins in Uterine Fibroids. Preprints 2023, 2023120648. https://doi.org/10.20944/preprints202312.0648.v1 Markowska, A.; De Mezer, M.; Kurzawa, P.; Bednarek, W.; Gryboś, A.; Krzyżaniak, M.; Markowska, J.; Gryboś, M.; Żurawski, J. Immunohistochemical Expression of the ANGPT1, Casr and PTK2 Proteins in Uterine Fibroids. Preprints 2023, 2023120648. https://doi.org/10.20944/preprints202312.0648.v1

Abstract

Understanding the molecular factors involved in the development of uterine myomas may result in the use of pharmacological drugs instead of aggressive surgical treatment. ANGPT1, CASR, and PTK2 were examined in myoma and peripheral tissues samples taken from women after myoma surgery and in normal uterine muscle tissue samples in the control group. Tests were performed using tissue microarray immunohistochemistry. No statistically significant differences in ANGPT1 expression between the tissue of the myoma, the periphery, and the normal uterine muscle tissue of the control group were recorded. The CASR value was reduced in the myoma and peripheral tissue and normal in the group of women without myomas. PTK2 expression was also lower in the myoma and periphery com-pared to healthy uterine myometrium. Calcium supplementation could have an effect on stop-ping the growth of myomas.

Keywords

uterine myoma; Angiopoietin 1; Calcium sensing receptor; Focal Adhesion Kinase

Subject

Medicine and Pharmacology, Pathology and Pathobiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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