Jonaitytė, I.R.; Karpavičiūtė, V.; Kiudelis, G.; Kupčinskas, J.; Jonaitis, L. Mucocutaneous Manifestations Reported by Inflammatory Bowel Disease Patients in University Hospital. Preprints2023, 2023120486. https://doi.org/10.20944/preprints202312.0486.v1
APA Style
Jonaitytė, I.R., Karpavičiūtė, V., Kiudelis, G., Kupčinskas, J., & Jonaitis, L. (2023). Mucocutaneous Manifestations Reported by Inflammatory Bowel Disease Patients in University Hospital. Preprints. https://doi.org/10.20944/preprints202312.0486.v1
Chicago/Turabian Style
Jonaitytė, I.R., Juozas Kupčinskas and Laimas Jonaitis. 2023 "Mucocutaneous Manifestations Reported by Inflammatory Bowel Disease Patients in University Hospital" Preprints. https://doi.org/10.20944/preprints202312.0486.v1
Abstract
Background and Objectives: Inflammatory bowel disease (IBD) may affect organs outside the intestines, it is called extraintestinal manifestations of IBD. Data on the prevalence of mucocutaneous manifestations in IBD patients are very limited, therefore, the aim of this study was to assess the prevalence of skin and mucosal lesions and to determine the relationship with demographic factors, clinical features, and systemic treatment. Materials and Methods: Prospective study included 162 out-patients with IBD who were managed in the tertiary care center. Ulcerative colitis (UC) was diagnosed in 117 patients, Crohn's disease (CD) in 45. Patients completed the questionnaire containing demographic and IBD data, questions about mucocutaneous lesions (in past or present state). Results: Skin lesions were reported by 40.7% of patients, oral mucosal lesions were reported by 16.7%, without significant differences between sexes or IBD types. In 47 (29%) of patients, skin lesions appeared together with IBD or during the course of the disease. The most common skin lesions were psoriasis (8.0%), erythema nodosum (5.6%), pyoderma gangrenosum and acne (3.7% each). UC patients mostly reported about psoriasis (9.4%), while CD patients – erythema nodosum (11.1%). There were more frequent skin lesions in patients with more extensive UC type (p = 0.01), while no difference was noticed between different types of CD. The average duration of IBD in patients with skin lesions was similar to those without lesions (9.3±6.7 vs. 9.4±6.7 years). Conclusions: Mucocutaneous lesions were reported by 48.8% of inflammatory bowel disease patients. The frequency of mucocutaneous lesions does not differ significantly between UC and CD, and a longer duration of illness is not a predictive factor for the appearance of lesions. More extensive UC is related to higher frequency of skin lesions.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
