Version 1
: Received: 4 December 2023 / Approved: 5 December 2023 / Online: 6 December 2023 (08:27:18 CET)
How to cite:
Qiu, H.; Zhong, Z.; Wu, T.; Hu, H.; Zhou, M.; Feng, Z. Evaluating the Causal Relationship of Levo-Carnitine and Risk of Schizophrenia: A Bidirectional Two-Sample Mendelian Randomization Study. Preprints2023, 2023120290. https://doi.org/10.20944/preprints202312.0290.v1
Qiu, H.; Zhong, Z.; Wu, T.; Hu, H.; Zhou, M.; Feng, Z. Evaluating the Causal Relationship of Levo-Carnitine and Risk of Schizophrenia: A Bidirectional Two-Sample Mendelian Randomization Study. Preprints 2023, 2023120290. https://doi.org/10.20944/preprints202312.0290.v1
Qiu, H.; Zhong, Z.; Wu, T.; Hu, H.; Zhou, M.; Feng, Z. Evaluating the Causal Relationship of Levo-Carnitine and Risk of Schizophrenia: A Bidirectional Two-Sample Mendelian Randomization Study. Preprints2023, 2023120290. https://doi.org/10.20944/preprints202312.0290.v1
APA Style
Qiu, H., Zhong, Z., Wu, T., Hu, H., Zhou, M., & Feng, Z. (2023). Evaluating the Causal Relationship of Levo-Carnitine and Risk of Schizophrenia: A Bidirectional Two-Sample Mendelian Randomization Study. Preprints. https://doi.org/10.20944/preprints202312.0290.v1
Chicago/Turabian Style
Qiu, H., Meijuan Zhou and Zhijun Feng. 2023 "Evaluating the Causal Relationship of Levo-Carnitine and Risk of Schizophrenia: A Bidirectional Two-Sample Mendelian Randomization Study" Preprints. https://doi.org/10.20944/preprints202312.0290.v1
Abstract
This study aims to investigate the causal relationship between Levo-carnitine (LC) and its derivatives and schizophrenia (SZ) using a Two-sample Mendelian randomization (MR) method. Forward MR analysis was conducted using LC and its derivatives as exposure and SZ as the outcome. Candidate data were obtained from the openGWAS server. Instrumental variables (IVs) were identified as single nucleotide polymorphisms (SNPs) closely associated with exposure, and were harmonized with the outcome data after removing confounders and outliers. Hence, MR analysis was performed using inverse variance weighting (IVW) as the primary approach, and sensitivity analysis was conducted to assess the reliability and robustness of the MR results. Finally, a reverse MR analysis was carried out using the same analytical procedures as the forward one. The MR results indicate a significant negative causal relationship between isovalery-LC and SZ (P < 0.05), but in no other groups (P>0.05). Additionally, the reverse MR analysis did not identify any causal relationship between SZ and LC related exposures (P>0.05). Sensitivity analyses, including pleiotropy and heterogeneity analysis, did not reveal any potential bias on the MR results (P>0.05). The results implied that elevated levels of isovalery-LC may potentially mitigate the risk of developing SZ, thereby highlighting the prospective therapeutic and preventive implications of isovalery-LC in the clinical management of SZ.Keywords: schizophrenia; levo-carnitine; carnitine; mendelian randomization
Medicine and Pharmacology, Psychiatry and Mental Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
