Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Investigating the Association Between Serum Biomarkers and Neonatal Sepsis in Newborns with Premature Rupture of Membranes: A Retrospective Study

Maura Adelina Hincu
ORCID logo ,
Gabriela Ildiko Zonda
* ORCID logo ,
Petronela Vicoveanu
* ,
Valeriu Harabor
,
Anamaria Harabor
,
Alexandru Cărăuleanu
,
Alina-Sinziana Melinte-Popescu
,
Marian Melinte-Popescu
,
Elena Mihalceanu
,
Mariana Stuparu Cretu
,
Ingrid Andrada Vasilache
ORCID logo ,
Dragos Nemescu
ORCID logo ,
Luminita Paduraru
ORCID logo
Version 1 : Received: 1 December 2023 / Approved: 4 December 2023 / Online: 4 December 2023 (14:17:49 CET)

A peer-reviewed article of this Preprint also exists.

Hincu, M.-A.; Zonda, G.-I.; Vicoveanu, P.; Harabor, V.; Harabor, A.; Carauleanu, A.; Melinte-Popescu, A.-S.; Melinte-Popescu, M.; Mihalceanu, E.; Stuparu-Cretu, M.; Vasilache, I.-A.; Nemescu, D.; Paduraru, L. Investigating the Association between Serum and Hematological Biomarkers and Neonatal Sepsis in Newborns with Premature Rupture of Membranes: A Retrospective Study. Children 2024, 11, 124. Hincu, M.-A.; Zonda, G.-I.; Vicoveanu, P.; Harabor, V.; Harabor, A.; Carauleanu, A.; Melinte-Popescu, A.-S.; Melinte-Popescu, M.; Mihalceanu, E.; Stuparu-Cretu, M.; Vasilache, I.-A.; Nemescu, D.; Paduraru, L. Investigating the Association between Serum and Hematological Biomarkers and Neonatal Sepsis in Newborns with Premature Rupture of Membranes: A Retrospective Study. Children 2024, 11, 124.

Abstract

(1) Background: Neonatal early-onset sepsis (EOS) is associated with important mortality and morbidity. The aims of this study were to evaluate the association between serum biomarkers with early onset neonatal sepsis in a cohort of patients with prolonged rupture of membranes (PROM), and to calculate their diagnostic accuracy. (2) Methods: A retrospective cohort study was conducted on 1355 newborns with PROM admitted between January 2017 and March 2020, who were divided in two groups: group A, with PROM ≥ 18 hours and group B, with PROM < 18 hours. Both groups were further split into subgroups: proven sepsis, probable sepsis and no sepsis. Descriptive statistics, ANOVA analysis, and a Random Effects Generalized Least Squares (GLS) regression were used to evaluate the data. (3) Results: The statistically significant predictors of neonatal sepsis were the high white blood cells count from the first (p = 0.005) and third day (p = 0.028), and high CRP values from the first day (p = 0.004). Procalcitonin (area under the curve - AUC = 0.78) and CRP (AUC = 0.76) measured on the first day had the best predictive performance for early onset neonatal sepsis. (4) Conclusions: Further studies are needed to explore other bi-omarkers of sepsis in both pregnant women and newborns to better predict EOS.

Keywords

Early-onset sepsis; Biomarker; C-reactive protein; Procalcitonin; White blood count; Antibiotics

Subject

Medicine and Pharmacology, Pediatrics, Perinatology and Child Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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