Version 1
: Received: 30 November 2023 / Approved: 1 December 2023 / Online: 1 December 2023 (11:47:15 CET)
How to cite:
FERRARI, I.V. Exploring the Potential Role of Hypericin in Targeting PIM1 for Cancer Research. Preprints2023, 2023120083. https://doi.org/10.20944/preprints202312.0083.v1
FERRARI, I.V. Exploring the Potential Role of Hypericin in Targeting PIM1 for Cancer Research. Preprints 2023, 2023120083. https://doi.org/10.20944/preprints202312.0083.v1
FERRARI, I.V. Exploring the Potential Role of Hypericin in Targeting PIM1 for Cancer Research. Preprints2023, 2023120083. https://doi.org/10.20944/preprints202312.0083.v1
APA Style
FERRARI, I.V. (2023). Exploring the Potential Role of Hypericin in Targeting PIM1 for Cancer Research. Preprints. https://doi.org/10.20944/preprints202312.0083.v1
Chicago/Turabian Style
FERRARI, I.V. 2023 "Exploring the Potential Role of Hypericin in Targeting PIM1 for Cancer Research" Preprints. https://doi.org/10.20944/preprints202312.0083.v1
Abstract
PIM1is involved in critical cellular processes, playing a key role in the regulation of the cell cycle, apoptosis, transcriptional activation, and broader signal transduction pathways . The exploration of PIM1inhibitors, such as small molecules or antibodies, represents a promising avenue in cancer research for developing novel treatment strategiess. Its significance in oncogenic signaling has led to extensive research on PIM1 as a target in cancer studies. Docking studies have revealed a robust interaction between hypericin and PIM1, suggesting a strong binding affinity (-12.5 kcal/mol). This research aims to explore the molecular dynamics of the hypericin-PIM1 interaction, identifying potential binding sites and elucidating the impact on PIM1-mediated cellular processes, such as cell cycle regulation and apoptosis. The findings may contribute valuable insights into developing hypericin-based therapies targeting PIM1, paving the way for novel and effective strategies in cancer research.
Keywords
PIM1 protein kinase ; hypericin ; docking analysis; cancer
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
