Review
Version 1
Preserved in Portico This version is not peer-reviewed
Hydrogel Microparticles for Bone Regeneration
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Version 1
: Received: 29 November 2023 / Approved: 30 November 2023 / Online: 30 November 2023 (14:15:08 CET)
A peer-reviewed article of this Preprint also exists.
Bektas, C.; Mao, Y. Hydrogel Microparticles for Bone Regeneration. Gels 2024, 10, 28. Bektas, C.; Mao, Y. Hydrogel Microparticles for Bone Regeneration. Gels 2024, 10, 28.
Abstract
The loss or dysfunction of skeletal tissue often necessitates surgical intervention, particularly in cases involving trauma, tumors, or abnormal development leading to critical-sized defects. Despite autografts being considered the gold standard for bone grafts, their limitations and complications prompt the exploration of alternative approaches for bone repair and regeneration. Current advancements in bone tissue engineering have led to innovative strategies aiming to regenerate injured bone structures, providing viable alternatives to traditional autografts or allografts. Among these strategies, Hydrogel Microparticles (HMPs) have emerged as promising scaffolds due to their notable characteristics, including high porosity and mechanical tunability. HMPs play an important role in facilitating vasculature formation, mineral deposition, and overall bone tissue regeneration. HMPs, fabricated through various techniques, exhibit versatility in functions such as drug and cell delivery, structural scaffolding, and bioinks for 3D printing. In addition, these microgels can be injected for minimally invasive delivery and can display modular properties with different designs and configurations. This review exclusively focuses on the advancements in HMPs for bone regeneration, delving into synthesis and functionalization techniques while highlighting their diverse applications documented in the literature. Our aim is to shed light on the unique benefits and potential of HMPs in the intricate field of engineering bone tissue.
Keywords
Hydrogel Microparticles; Microgels; Bone Tissue Engineering; Bone Regeneration; Cell Delivery; Bioactive Factor Delivery; HMP-based scaffolds; HMP incorporated scaffolds
Subject
Biology and Life Sciences, Biology and Biotechnology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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