Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Hepatitis C Virus and the Host: A Mutual Endurance Leaving Indelible Scars in Host’s Immunity

Mario U Mondelli
* ,
Sabrina Ottolini
ORCID logo ,
Barbara Oliviero
,
Stefania Mantovani
ORCID logo ,
Antonella Cerino
,
Dalila Mele
,
Stefania Varchetta
ORCID logo
Version 1 : Received: 29 November 2023 / Approved: 30 November 2023 / Online: 30 November 2023 (10:41:51 CET)

A peer-reviewed article of this Preprint also exists.

Mondelli, M.U.; Ottolini, S.; Oliviero, B.; Mantovani, S.; Cerino, A.; Mele, D.; Varchetta, S. Hepatitis C Virus and the Host: A Mutual Endurance Leaving Indelible Scars in the Host’s Immunity. Int. J. Mol. Sci. 2024, 25, 268. Mondelli, M.U.; Ottolini, S.; Oliviero, B.; Mantovani, S.; Cerino, A.; Mele, D.; Varchetta, S. Hepatitis C Virus and the Host: A Mutual Endurance Leaving Indelible Scars in the Host’s Immunity. Int. J. Mol. Sci. 2024, 25, 268.

Abstract

Hepatitis C virus (HCV) is diffused worldwide, and it is responsible for potentially severe chronic liver disease and primary liver cancer. Chronic infection remains for life if not spontaneously eliminated and viral persistence profoundly impairs the efficiency of host’s immunity. Attempts have been made to develop an effective vaccine, but efficacy trials have met with failure. The availability of highly efficacious direct acting antivirals (DAA) has shed hopes for progressive elimination of chronic HCV infection; however, this approach requires a global monumental effort. Moreover, DAA treatment does not completely restore the normal immunologic homeostasis. Here we discuss the main immunological features of immune responses to HCV and the epigenetic scars that chronic viral persistence leaves behind.

Keywords

HCV; Innate immunity; Adaptive immunity

Subject

Biology and Life Sciences, Immunology and Microbiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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