Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Molecular Mechanisms Involved in the Occurrence and Progression of Long COVID and Associated Analysis Techniques

Adela Constantinescu-Bercu
,
Andrei Lobiuc
* ,
Olga Adriana Caliman Sturdza
ORCID logo ,
Radu Oita
,
Monica Iavorschi
,
Naomi Paval
,
Iuliana Soldanescu
,
Mihai Dimian
ORCID logo ,
Mihai Covasa
Version 1 : Received: 29 November 2023 / Approved: 29 November 2023 / Online: 29 November 2023 (10:54:33 CET)

A peer-reviewed article of this Preprint also exists.

Constantinescu-Bercu, A.; Lobiuc, A.; Căliman-Sturdza, O.A.; Oiţă, R.C.; Iavorschi, M.; Pavăl, N.-E.; Șoldănescu, I.; Dimian, M.; Covasa, M. Long COVID: Molecular Mechanisms and Detection Techniques. Int. J. Mol. Sci. 2024, 25, 408. Constantinescu-Bercu, A.; Lobiuc, A.; Căliman-Sturdza, O.A.; Oiţă, R.C.; Iavorschi, M.; Pavăl, N.-E.; Șoldănescu, I.; Dimian, M.; Covasa, M. Long COVID: Molecular Mechanisms and Detection Techniques. Int. J. Mol. Sci. 2024, 25, 408.

Abstract

Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection (PASC), has emerged as a significant health concern following the COVID-19 pandemic. Molecular mechanisms underlying the occurrence and progression of long COVID include viral persistence, immune dysregulation, endothelial dysfunction, and neurological involvement, and highlight the need for further research to develop targeted therapies for this condition. While a clearer picture of the clinical symptomatology is shaping, many molecular mechanisms are yet to be unraveled, given their complexity and high level of interaction with other metabolic pathways. This review summarizes some of the most important symptoms and associated molecular mechanisms that occur in long COVID, as well as the most relevant molecular techniques that can be used in understanding the viral pathogen, its affinity towards the host and the possible outcomes of host-pathogen interaction.

Keywords

immunity; inflammation; SARS-CoV-2; gene expression; sequencing

Subject

Biology and Life Sciences, Life Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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