Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Aquaporin Expression and Regulation in Clinical and Experimental Sepsis

Nikolaos S. Lotsios
,
Chrysi Keskinidou
ORCID logo ,
Ioanna Dimopoulou
ORCID logo ,
Αnastasia Kotanidou
ORCID logo ,
Stylianos E. Orfanos
,
Alice G. Vassiliou
* ORCID logo
Version 1 : Received: 24 November 2023 / Approved: 27 November 2023 / Online: 27 November 2023 (04:12:50 CET)

A peer-reviewed article of this Preprint also exists.

Lotsios, N.S.; Keskinidou, C.; Dimopoulou, I.; Kotanidou, Α.; Orfanos, S.E.; Vassiliou, A.G. Aquaporin Expression and Regulation in Clinical and Experimental Sepsis. Int. J. Mol. Sci. 2024, 25, 487. Lotsios, N.S.; Keskinidou, C.; Dimopoulou, I.; Kotanidou, Α.; Orfanos, S.E.; Vassiliou, A.G. Aquaporin Expression and Regulation in Clinical and Experimental Sepsis. Int. J. Mol. Sci. 2024, 25, 487.

Abstract

Sepsis is an inflammatory disorder caused by the host’s dysfunctional response to infection. Septic patients present diverse clinical characteristics, and in the recent years it has been the main cause of death in intensive care units (ICU). Aquaporins, membrane proteins with role in water transportation, have been reported to participate in numerous biological processes. Their role in sepsis progression has been studied extensively. This review aims to examine recent literature on aquaporin expression and regulation in clinical sepsis, as well as established experimental models of sepsis. We will present how sepsis affects aquaporin expression at the molecular and protein level. Moreover, we will delve into the importance of aquaporin regulation at the transcriptional, post-transcriptional, translational, and post-translational level in sepsis, by presenting data on aquaporin regulation by non-coding RNAs and selected chemical molecules. Finally, we will focus on the importance of aquaporin single nucleotide polymorphisms in the setting of sepsis.

Keywords

aquaporin; sepsis; ARDS; SNP; lnRNA; miRNA

Subject

Medicine and Pharmacology, Pathology and Pathobiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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