Version 1
: Received: 24 November 2023 / Approved: 24 November 2023 / Online: 24 November 2023 (11:35:35 CET)
How to cite:
Lee, J.; Bae, A.; Park, J.; Lee, J.; Hong, C.; Jung, S. Clinical Features and Significance of Tuberous Sclerosis 1 and Tuberous Sclerosis 2 Gene Expression in Rectal Cancer. Preprints2023, 2023111602. https://doi.org/10.20944/preprints202311.1602.v1
Lee, J.; Bae, A.; Park, J.; Lee, J.; Hong, C.; Jung, S. Clinical Features and Significance of Tuberous Sclerosis 1 and Tuberous Sclerosis 2 Gene Expression in Rectal Cancer. Preprints 2023, 2023111602. https://doi.org/10.20944/preprints202311.1602.v1
Lee, J.; Bae, A.; Park, J.; Lee, J.; Hong, C.; Jung, S. Clinical Features and Significance of Tuberous Sclerosis 1 and Tuberous Sclerosis 2 Gene Expression in Rectal Cancer. Preprints2023, 2023111602. https://doi.org/10.20944/preprints202311.1602.v1
APA Style
Lee, J., Bae, A., Park, J., Lee, J., Hong, C., & Jung, S. (2023). Clinical Features and Significance of Tuberous Sclerosis 1 and Tuberous Sclerosis 2 Gene Expression in Rectal Cancer. Preprints. https://doi.org/10.20944/preprints202311.1602.v1
Chicago/Turabian Style
Lee, J., Chang-Won Hong and Soo-Jung Jung. 2023 "Clinical Features and Significance of Tuberous Sclerosis 1 and Tuberous Sclerosis 2 Gene Expression in Rectal Cancer" Preprints. https://doi.org/10.20944/preprints202311.1602.v1
Abstract
Background and objectives: TSC1 is a crucial component of the mTOR pathway, impacting cell growth, proliferation, and autophagy, while TSC2 is a tumor suppressor gene that regulates cell growth and is associated with the mTOR signaling pathway. In the present study, we analyzed TSC1 and TSC2 mRNA expression levels in rectal cancer, and evaluated the clinicopathological and prognostic characteristics of TSC1 and TSC2. Materials and Methods: TSC1 and TSC2 mRNA expression was examined in various cancer types. We further evaluated survival to determine the prognostic significance of TSC1 and TSC2 mRNA in CRC using The Cancer Genome Atlas (TCGA) data. Results: The study focused on rectal cancer, as it exhibited the most promising results. The patients were split into two subgroups, each comprising 50% of the total, based on the TSC gene expression levels. This division was made to assess the clinical characteristics associated with the expression of TSC1 and TSC2 genes. In the study, lower TSC1 expression was linked to venous invasion in rectal cancer patients, and there was also a related trend with lymphatic invasion, although it didn't reach statistical significance. Lower TSC2 expression was observed in younger patients and had some associations with sex and M stage, but these correlations were not statistically significant. When it came to survival analysis, TSC1 expression did not significantly impact overall survival, while higher TSC2 expression was associated with a poorer prognosis in rectal cancer. To enhance our comprehension, additional research, especially in larger case studies, is needed to explore the molecular mechanisms and clinical characteristics of TSC genes in colorectal cancer.
Keywords
Colorectal cancer; Tuberous sclerosis; The Cancer Genome Atlas
Subject
Biology and Life Sciences, Biology and Biotechnology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
