PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Longitudinal Associations of Dietary Fructose and
Psychological Stress with Vascular Aging Index and
Incident Cardiovascular Disease in the CARDIA Cohort
Osborne, M.; Bernard, A.; Falkowski, E.; Peterson, D.; Vavilikolanu, A.; Komnenov, D. Longitudinal Associations of Dietary Fructose, Sodium, and Potassium and Psychological Stress with Vascular Aging Index and Incident Cardiovascular Disease in the CARDIA Cohort. Nutrients2024, 16, 127.
Osborne, M.; Bernard, A.; Falkowski, E.; Peterson, D.; Vavilikolanu, A.; Komnenov, D. Longitudinal Associations of Dietary Fructose, Sodium, and Potassium and Psychological Stress with Vascular Aging Index and Incident Cardiovascular Disease in the CARDIA Cohort. Nutrients 2024, 16, 127.
Osborne, M.; Bernard, A.; Falkowski, E.; Peterson, D.; Vavilikolanu, A.; Komnenov, D. Longitudinal Associations of Dietary Fructose, Sodium, and Potassium and Psychological Stress with Vascular Aging Index and Incident Cardiovascular Disease in the CARDIA Cohort. Nutrients2024, 16, 127.
Osborne, M.; Bernard, A.; Falkowski, E.; Peterson, D.; Vavilikolanu, A.; Komnenov, D. Longitudinal Associations of Dietary Fructose, Sodium, and Potassium and Psychological Stress with Vascular Aging Index and Incident Cardiovascular Disease in the CARDIA Cohort. Nutrients 2024, 16, 127.
Abstract
We explored how dietary behaviors (sucrose, fructose, sodium, and potassium consumption) and endured psychological stress in young adult males and females impact the vascular aging index (VAI) and CVD risk by mid-life. Data were obtained from the Coronary Artery Risk Development in Young Adults Study, an ongoing longitudinal study. Included participants (n=2,656) had un-dergone carotid artery ultrasound at year 20 allowing VAIs to be calculated. Demographics, di-etary data and depression scores were obtained at baseline and year 20. Regression analyses were used to assess the predictors of VAI. Cox regression analyses were conducted to assess the risk of CVD, stroke and all-cause mortality. Predictors of vascular aging were found to be sex-specific. In females, CES-D scores at baseline were positively associated with VAI (B-weight=0.063, p=0.015). In males, sodium intake at year 20 positively predicted VAI (B-weight=0.145, p=0.003) and potassium intake inversely predicted VAI (B-weight=-0.160, p<0.001). BMI significantly predicted CVD, stroke, and death. Fructose consumption at year 20 was a significant predictor of CVD risk while having high blood pressure at baseline was signif-icantly associated with stroke risk. Our findings support the promotion of nutrient- specific be-havior changes to prevent vascular aging in early adulthood and CVD risk in mid-life.
Keywords
vascular aging; cardiovascular disease; lifestyle
Subject
Biology and Life Sciences, Life Sciences
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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