Khouri, A.; Moreno, C.G.; Di Palma, J.A. Bowel Cleansing Preparations Are Associated with Gastroduodenal Lesions. Gastrointestinal Disorders 2024, 6, 359–367, doi:10.3390/gidisord6010024.
Khouri, A.; Moreno, C.G.; Di Palma, J.A. Bowel Cleansing Preparations Are Associated with Gastroduodenal Lesions. Gastrointestinal Disorders 2024, 6, 359–367, doi:10.3390/gidisord6010024.
Khouri, A.; Moreno, C.G.; Di Palma, J.A. Bowel Cleansing Preparations Are Associated with Gastroduodenal Lesions. Gastrointestinal Disorders 2024, 6, 359–367, doi:10.3390/gidisord6010024.
Khouri, A.; Moreno, C.G.; Di Palma, J.A. Bowel Cleansing Preparations Are Associated with Gastroduodenal Lesions. Gastrointestinal Disorders 2024, 6, 359–367, doi:10.3390/gidisord6010024.
Abstract
Background: During esophagogastroduodenoscopy performed with colonoscopy, gastric and duodenal erythema, erosions, and ulcerations are often observed. This investigation was designed to review the prevalence of gastroduodenal lesions in patients who underwent wireless capsule endoscopy using standard bowel cleansing preparations, but no endoscopy or sedation. Methods: A retrospective analysis was conducted on patients referred for capsule endoscopy. Records and capsule reports were reviewed for patient demographics, preparation prescribed, procedural indications, and gastroduodenal findings. Preparations studied included polyethylene glycol lavage (PEG), PEG plus bisacodyl (PEG+bis), bisacodyl (bis), oral sulfate solution (OSS) and no prep. Results: Among the 1236 records, 498 (40.3%) were men and 738 (59.7%) were women. The mean age was 57 years +/- 17.8 years SD. The percentage of patients with lesions after any bowel preparation was 52.7% for gastric lesions and 23.6% for duodenal lesions. The percentage of patients with gastroduodenal lesions was 58.3% with prep, compared to 38.2% without prep. These findings were statistically significant with RR 1.53 [1.19-1.94] (p-value=0.00004). This difference was more pronounced in the OSS group RR 1.65 [1.29-2.1] and bisacodyl groups RR 1.64 [1.25-2.15] compared to the PEG group RR 0.95 [0.7-1.3]. Conclusion: This study showed that patients undergoing wireless capsule endoscopy who received bowel preparations had a significant increase in gastric and duodenal lesions. Of the preparations studied, OSS was associated with the greater number of gastroduodenal lesions, while PEG was the least associated with lesions with an occurrence similar to the non-prep group. The clinical significance of these lesions remains undetermined.
Medicine and Pharmacology, Gastroenterology and Hepatology
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