Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Hyperimmune Plasma and Immunoglobulins Against COVID-19: A Narrative Review

Version 1 : Received: 21 November 2023 / Approved: 21 November 2023 / Online: 22 November 2023 (02:29:07 CET)

A peer-reviewed article of this Preprint also exists.

Franchini, M.; Focosi, D. Hyperimmune Plasma and Immunoglobulins against COVID-19: A Narrative Review. Life 2024, 14, 214. Franchini, M.; Focosi, D. Hyperimmune Plasma and Immunoglobulins against COVID-19: A Narrative Review. Life 2024, 14, 214.

Abstract

Since late 2019, COVID-19, a severe acute respiratory syndrome pandemic, was caused by the new SARS-CoV-2 virus belonging to the Coronaviridae family, . Several antiviral therapies, mostly derived from previous epidemics, were initially repurposed to fight this not rarely life-threatening respiratory illness. Among them, however, the only specific antibody-based therapy available against SARS-CoV-2 infection during the first year of the pandemic was represented by COVID-19 convalescent plasma (CCP). CCP, collected from recovered individuals, contains high levels of polyclonal antibodies of different subclasses able to neutralize SARS-CoV-2 infection. Tens of randomized controlled trials have been conducted during the last three years of the pandemic to evaluate the safety and the clinical efficacy of CCP in both hospitalized and ambulatory COVID-19 patients, whose main results will be summarized in this narrative review. In addition, we will present the current knowledge on the development of anti-SARS-CoV-2 hyperimmune polyclonal immunoglobulins.

Keywords

COVID-19; SARS-CoV-2; convalescent plasma; hyperimmune immunoglobulins

Subject

Public Health and Healthcare, Other

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