Version 1
: Received: 18 November 2023 / Approved: 20 November 2023 / Online: 21 November 2023 (07:19:23 CET)
How to cite:
Apostle, A.; Arneson, R.; Yuan, Y.; Fang, S. The Naturally Occurring m1A RNA Modification Can Be Efficiently Incorporated into RNA by SARS-CoV-2 RdRp. Preprints2023, 2023111268. https://doi.org/10.20944/preprints202311.1268.v1
Apostle, A.; Arneson, R.; Yuan, Y.; Fang, S. The Naturally Occurring m1A RNA Modification Can Be Efficiently Incorporated into RNA by SARS-CoV-2 RdRp. Preprints 2023, 2023111268. https://doi.org/10.20944/preprints202311.1268.v1
Apostle, A.; Arneson, R.; Yuan, Y.; Fang, S. The Naturally Occurring m1A RNA Modification Can Be Efficiently Incorporated into RNA by SARS-CoV-2 RdRp. Preprints2023, 2023111268. https://doi.org/10.20944/preprints202311.1268.v1
APA Style
Apostle, A., Arneson, R., Yuan, Y., & Fang, S. (2023). The Naturally Occurring m<sup>1</sup>A RNA Modification Can Be Efficiently Incorporated into RNA by SARS-CoV-2 RdRp. Preprints. https://doi.org/10.20944/preprints202311.1268.v1
Chicago/Turabian Style
Apostle, A., Yinan Yuan and Shiyue Fang. 2023 "The Naturally Occurring m<sup>1</sup>A RNA Modification Can Be Efficiently Incorporated into RNA by SARS-CoV-2 RdRp" Preprints. https://doi.org/10.20944/preprints202311.1268.v1
Abstract
When it is in the template RNA, the naturally occurring m1A epitranscriptomic RNA modification was recently reported to be able to stop the RNA polymerization reaction catalyzed by the RNA dependent RNA polymerase (RdRp) of SARS-CoV-2. In this report, we report that m1A via its triphosphate form (m1ATP) can be incorporated into RNA by the same RdRp. These two findings point a new direction for antiviral drug development based on m1A for combatting COVID-19. More broadly, it is possible that the large pool of epigenetic RNA as well as DNA modifications could serve as a treasury for drug discovery aimed at combating various infectious and other diseases.
Keywords
SARS-CoV-2; COVID-19; RdRp; m1A triphosphate; Antiviral Drug
Subject
Biology and Life Sciences, Life Sciences
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
