Enterococcal Faecalis Endocarditis in Renal Transplant Patients: Our Experience with Ampicillin and Daptomycin Combination

Fernando Baires; Erin Arias; Maria Jose Diaz Ramos; Cesar Burgos; Guillermo Lopez; Juan S Llompart; Jana Radwanski; Tywaun Tillman; Fernando Valerio; Anupamjeet Kaur Sekhon; Jarmanjeet Singh; Chetan Jinadatha; Miguel Sierra-Hoffman; Mark L Stevens

doi:10.20944/preprints202311.1172.v1

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preprints.org > medicine and pharmacology > cardiac and cardiovascular systems > doi: 10.20944/preprints202311.1172.v1

Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

Enterococcal Faecalis Endocarditis in Renal Transplant Patients: Our Experience with Ampicillin and Daptomycin Combination

Fernando Baires

Erin Arias

Maria Jose Diaz Ramos

Anupamjeet Kaur Sekhon

Jarmanjeet Singh

Chetan Jinadatha

Miguel Sierra-Hoffman

^* ,

Mark L Stevens

Version 1 : Received: 16 November 2023 / Approved: 16 November 2023 / Online: 21 November 2023 (10:15:46 CET)

How to cite: Baires, F.; Arias, E.; Ramos, M.J.D.; Burgos, C.; Lopez, G.; Llompart, J.S.; Radwanski, J.; Tillman, T.; Valerio, F.; Sekhon, A.K.; Singh, J.; Jinadatha, C.; Sierra-Hoffman, M.; Stevens, M.L. Enterococcal Faecalis Endocarditis in Renal Transplant Patients: Our Experience with Ampicillin and Daptomycin Combination. Preprints 2023, 2023111172. https://doi.org/10.20944/preprints202311.1172.v1 Baires, F.; Arias, E.; Ramos, M.J.D.; Burgos, C.; Lopez, G.; Llompart, J.S.; Radwanski, J.; Tillman, T.; Valerio, F.; Sekhon, A.K.; Singh, J.; Jinadatha, C.; Sierra-Hoffman, M.; Stevens, M.L. Enterococcal Faecalis Endocarditis in Renal Transplant Patients: Our Experience with Ampicillin and Daptomycin Combination. Preprints 2023, 2023111172. https://doi.org/10.20944/preprints202311.1172.v1

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MDPI and ACS Style

Baires, F.; Arias, E.; Ramos, M.J.D.; Burgos, C.; Lopez, G.; Llompart, J.S.; Radwanski, J.; Tillman, T.; Valerio, F.; Sekhon, A.K.; Singh, J.; Jinadatha, C.; Sierra-Hoffman, M.; Stevens, M.L. Enterococcal Faecalis Endocarditis in Renal Transplant Patients: Our Experience with Ampicillin and Daptomycin Combination. Preprints 2023, 2023111172. https://doi.org/10.20944/preprints202311.1172.v1

APA Style

Baires, F., Arias, E., Ramos, M.J.D., Burgos, C., Lopez, G., Llompart, J.S., Radwanski, J., Tillman, T., Valerio, F., Sekhon, A.K., Singh, J., Jinadatha, C., Sierra-Hoffman, M., & Stevens, M.L. (2023). Enterococcal Faecalis Endocarditis in Renal Transplant Patients: Our Experience with Ampicillin and Daptomycin Combination. Preprints. https://doi.org/10.20944/preprints202311.1172.v1

Chicago/Turabian Style

Baires, F., Miguel Sierra-Hoffman and Mark L Stevens. 2023 "Enterococcal Faecalis Endocarditis in Renal Transplant Patients: Our Experience with Ampicillin and Daptomycin Combination" Preprints. https://doi.org/10.20944/preprints202311.1172.v1

Abstract

Globally, the adoption of Solid Organ Transplantation (SOT) as first-line therapy for end-stage organ failure has not come without its share of complications. Enterococcal endocarditis poses a substantial risk to renal transplant patients, and multiple factors must be considered due to the grave nature of this infection. Such factors include addressing multidrug-resistant organisms, antibiotic therapy-related toxicity, and preserving the transplanted organ. Additional considerations include salvaging an affected cardiac valve and avoiding the need for a valve replacement with the attendant complications. Ampicillin and gentamicin have historically been the standard of care as first-line treatment for many years until the aminoglycoside sparing regimen of ampicillin and ceftriaxone showed non-inferiority in clinical studies. We present a second case report with an aminoglycoside sparing regimen of ampicillin and daptomycin in a renal transplant patient who developed Enterococcus faecalis endocarditis. We conclude with a brief review of published research with this combination.

Keywords

endocarditis; enterococcal; daptomycin; transplant; ampicillin

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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