Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Efficient Hydroxyapatite Extraction from Salmon Bone Waste: An Improved Lab-Scaled Physico-Chemico-Biological Process

Version 1 : Received: 16 November 2023 / Approved: 16 November 2023 / Online: 17 November 2023 (08:43:27 CET)
Version 2 : Received: 8 July 2024 / Approved: 9 July 2024 / Online: 9 July 2024 (10:47:28 CEST)

How to cite: Muñoz, F.; Guerra, I.; Garcia, M. J.; Enrione, J.; Ortega, N.; Haidar, Z. S. Efficient Hydroxyapatite Extraction from Salmon Bone Waste: An Improved Lab-Scaled Physico-Chemico-Biological Process. Preprints 2023, 2023111090. https://doi.org/10.20944/preprints202311.1090.v1 Muñoz, F.; Guerra, I.; Garcia, M. J.; Enrione, J.; Ortega, N.; Haidar, Z. S. Efficient Hydroxyapatite Extraction from Salmon Bone Waste: An Improved Lab-Scaled Physico-Chemico-Biological Process. Preprints 2023, 2023111090. https://doi.org/10.20944/preprints202311.1090.v1

Abstract

Salmon aquaculture generates a substantial volume of waste material, offering potential for biomaterial production. This industry produces significant waste, which can be repurposed for various biological applications, particularly in biomaterial production for tissue engineering with pertinent applications in osteo-conduction, osteo-induction, and clinical/surgical bone regeneration and repair. The process involves a standardized pre-treatment stage aimed at minimizing biological waste content. Subsequently, the treatment stage, contingent on the chosen methodology, facilitates the removal of proteins, lipids, and other compounds, leaving the mineral phase as a valuable substrate. The selection of the optimal method, whether alkaline hydrolysis, calcination, or NaOH hydrolysis, for obtaining this substrate necessitates thorough examination through chemical, physical, and biological assessments, including Raman Spectroscopy and X-Ray Diffraction. This study aims to identify the most efficient approach for hydroxyapatite production derived from salmon waste.

Keywords

Hydroxyapatite; Salmon Bone; Bone Repair; Osteoregeneration; Process; Biomaterial

Subject

Biology and Life Sciences, Biology and Biotechnology

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