Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Effect of the Flavonoid Rutin on the Modulation of the Enteric Nervous System in Experimental Model of Parkinson’s Disease.

Livia Bacelar De Jesus
,
Annyta Frota
,
Fillipe Mendes De Araújo
,
Rafael Leonne Cruz de Jesus Jesus
,
Maria de Fatima Dias Costa
,
Darizy Flavia Silva
,
Marcelo Biondaro Gois
ORCID logo ,
Gyselle Chrystina Baccan
,
Victor Diogenes Amaral Da Silva
* ,
Silvia Lima Costa
* ORCID logo
Version 1 : Received: 15 November 2023 / Approved: 16 November 2023 / Online: 16 November 2023 (09:26:54 CET)

How to cite: De Jesus, L.B.; Frota, A.; De Araújo, F.M.; Jesus, R.L.C.D.J.; Costa, M.D.F.D.; Silva, D.F.; Gois, M.B.; Baccan, G.C.; Da Silva, V.D.A.; Costa, S.L. Effect of the Flavonoid Rutin on the Modulation of the Enteric Nervous System in Experimental Model of Parkinson’s Disease.. Preprints 2023, 2023111071. https://doi.org/10.20944/preprints202311.1071.v1 De Jesus, L.B.; Frota, A.; De Araújo, F.M.; Jesus, R.L.C.D.J.; Costa, M.D.F.D.; Silva, D.F.; Gois, M.B.; Baccan, G.C.; Da Silva, V.D.A.; Costa, S.L. Effect of the Flavonoid Rutin on the Modulation of the Enteric Nervous System in Experimental Model of Parkinson’s Disease.. Preprints 2023, 2023111071. https://doi.org/10.20944/preprints202311.1071.v1

Abstract

Recent discoveries have shown that enteric glial cells play an important role in different neurodegenerative disorders such as Parkinson's disease (PD), which is characterized by motor dysfunctions caused by progressive loss of dopaminergic neurons in the substance nigra pars compacta and non-motor symptoms including gastrointestinal dysfunction. In this study we observed the modulatory effects of the flavonoid rutin on enteric glia in a PD animal model. Adult male Wistar rats were submitted to stereotaxic injection with 6-hydroxydopamine or saline, treated or not with rutin (10 mg/Kg) for 14 days. Intestinal segments (ileum and colon) were collected to analyze tissue reactivity and immunohistochemistry for neurons (HUc/d) and enteric glial cells (S100b) in the myoenteric plexuses. Behavioral tests demonstrated that treatment with rutin im-proved the motor capacity of parkinsonian animals, and also improved intestinal transit without interfering with the cell population; rutin treatment modulated reactivity of the ileal musculature by muscarinic activation, reducing relaxation through the signaling pathway of nitric oxide donors, and increasing the longitudinal contractility of the colon musculature in parkinsonian animals. Rutin demonstrated modulatory activities on the enteric nervous system, bringing relevant answers about the effect of the flavonoid in this system and po-tential application for PD adjuvant treatment.

Keywords

rutin; enteric nervous system; Parkinson's disease

Subject

Medicine and Pharmacology, Complementary and Alternative Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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