Photo- and X-ray Induced Cytotoxicity of CeF3-YF3-TbF3 Nano-Particle- Polyvinylpyrrolidone –“Radachlorin” Composites for Combined Photodynamic Therapy

Alina Khusainova; Alexey Nizamutdinov; Nail Shamsutdinov; Svetlana Kalinichenko; Damir Safin; Marat Gafurov; Elena Lukinova; Sergey Batygov; Sergey Kuznetsov; Sergey Zinchenko; Pavel Zelenikhin; Maksim Pudovkin

doi:10.20944/preprints202311.1050.v1

A peer-reviewed article of this Preprint also exists.

Khusainova, A.I.; Nizamutdinov, A.S.; Shamsutdinov, N.I.; Kalinichenko, S.; Safin, D.I.; Gafurov, M.; Lukinova, E.V.; Batygov, S.K.; Kuznetsov, S.V.; Zinchenko, S.V.; Zelenikhin, P.V.; Pudovkin, M. Photo- and X-ray Induced Cytotoxicity of CeF₃-YF₃-TbF₃ Nanoparticle-Polyvinylpyrrolidone—“Radachlorin” Composites for Combined Photodynamic Therapy. Materials 2024, 17, 316. Khusainova, A.I.; Nizamutdinov, A.S.; Shamsutdinov, N.I.; Kalinichenko, S.; Safin, D.I.; Gafurov, M.; Lukinova, E.V.; Batygov, S.K.; Kuznetsov, S.V.; Zinchenko, S.V.; Zelenikhin, P.V.; Pudovkin, M. Photo- and X-ray Induced Cytotoxicity of CeF3-YF3-TbF3 Nanoparticle-Polyvinylpyrrolidone—“Radachlorin” Composites for Combined Photodynamic Therapy. Materials 2024, 17, 316.

Abstract

The Ce0.5Y0.35Tb0.15F3 nanoparticles with CeF3 hexagonal structure were synthesized by co-precipitation technique. The average nanoparticle diameter was 14±1 nm. The luminescence decay curves of Ce0.5Y0.35Tb0.15F3 nanoparticles (λem = 541 nm, 5D4 – 7F5 transition of Tb3+) conjugated with Radachlorin by means of polyvinylpyrrolidone coating as well as without Radachlorin were detected. Efficient nonradiative energy transfer from Tb3+ to the Radachlorin was demonstrated. The maximum energy transfer coefficient for nanoparticles conjugated with Radachlorin via polyvinylpyrrolidone and without the coating were 82% and 55%, respectively. The average distance between nanoparticle surface and Radachlorin was R0 =4.5 nm. The best results for X-ray induced cytotoxicity was observed for NP-PVP-Rch sample at the lowest Rch concentration. In particular, after X-ray irradiation the survival A 549 human lung carcinoma cells decreased by ~12%.

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Photo- and X-ray Induced Cytotoxicity of CeF₃-YF₃-TbF₃ Nano-Particle- Polyvinylpyrrolidone –“Radachlorin” Composites for Combined Photodynamic Therapy

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