Effect of Specific Probiotic Mixture on Coronavirus (FeCoV) Viral Load in 25 Naturally-Infected, Clinically Healthy, Purebred Birmanian Cats

Sara Mangiaterra; Matteo Cerquetella; Alessandra Gavazza; Maria Elena Turba; Sara Berardi; Lucia Biagini; Giacomo Rossi

doi:10.20944/preprints202311.1042.v3

Submit preprint
How it Works
Instructions for Authors
Subject Areas
Advisory Board
screening preprints
About
Awards
Log in/Register

Instructions for Authors
Awards
About
FAQ
Submit Log in/Register

Share this article with

Create alert

Email:

Load new image

preprints.org > medicine and pharmacology > veterinary medicine > doi: 10.20944/preprints202311.1042.v3

Preprint Communication Version 3 Preserved in Portico This version is not peer-reviewed

Effect of Specific Probiotic Mixture on Coronavirus (FeCoV) Viral Load in 25 Naturally-Infected, Clinically Healthy, Purebred Birmanian Cats

^* ,

Version 1 : Received: 15 November 2023 / Approved: 16 November 2023 / Online: 16 November 2023 (02:58:30 CET)
Version 2 : Received: 16 November 2023 / Approved: 17 November 2023 / Online: 17 November 2023 (04:38:13 CET)
Version 3 : Received: 19 November 2023 / Approved: 20 November 2023 / Online: 20 November 2023 (05:37:53 CET)

How to cite: Mangiaterra, S.; Cerquetella, M.; Gavazza, A.; Turba, M.E.; Berardi, S.; Biagini, L.; Rossi, G. Effect of Specific Probiotic Mixture on Coronavirus (FeCoV) Viral Load in 25 Naturally-Infected, Clinically Healthy, Purebred Birmanian Cats. Preprints 2023, 2023111042. https://doi.org/10.20944/preprints202311.1042.v3 Mangiaterra, S.; Cerquetella, M.; Gavazza, A.; Turba, M.E.; Berardi, S.; Biagini, L.; Rossi, G. Effect of Specific Probiotic Mixture on Coronavirus (FeCoV) Viral Load in 25 Naturally-Infected, Clinically Healthy, Purebred Birmanian Cats. Preprints 2023, 2023111042. https://doi.org/10.20944/preprints202311.1042.v3

Cite

Export citation file: Bib TeX | RIS

MDPI and ACS Style

Mangiaterra, S.; Cerquetella, M.; Gavazza, A.; Turba, M.E.; Berardi, S.; Biagini, L.; Rossi, G. Effect of Specific Probiotic Mixture on Coronavirus (FeCoV) Viral Load in 25 Naturally-Infected, Clinically Healthy, Purebred Birmanian Cats. Preprints 2023, 2023111042. https://doi.org/10.20944/preprints202311.1042.v3

APA Style

Mangiaterra, S., Cerquetella, M., Gavazza, A., Turba, M.E., Berardi, S., Biagini, L., & Rossi, G. (2023). Effect of Specific Probiotic Mixture on Coronavirus (FeCoV) Viral Load in 25 Naturally-Infected, Clinically Healthy, Purebred Birmanian Cats. Preprints. https://doi.org/10.20944/preprints202311.1042.v3

Chicago/Turabian Style

Mangiaterra, S., Lucia Biagini and Giacomo Rossi. 2023 "Effect of Specific Probiotic Mixture on Coronavirus (FeCoV) Viral Load in 25 Naturally-Infected, Clinically Healthy, Purebred Birmanian Cats" Preprints. https://doi.org/10.20944/preprints202311.1042.v3

Abstract

Feline coronavirus (FeCoV) causes enteric disease in cat worldwide. In general, FeCoV infection is characterized by self- limiting gastroenteritis but not understood changes can give rise to mutants that lead to the development of feline infectious peritonitis (FIP). In cats, FeCoV replicates in the intestines and spreads by fecal-oral transmission and persists in multi-cats households by infec-tion and re-infection by the same or another viral strain. Although current evidence shows that probiotics have promise for enhancing health benefits protecting from viral infection, today there are no studies regarding the use of probiotics in reducing fecal emission of feline coronavirus in naturally infected cats. The aim of the present study was to evaluate the effect of specific mul-ti-strain probiotics on FeCoV viral load in 25 naturally-infected cats. The study population con-sisted of purebred Birmanian cats, of which 14 females and 11 males, aged from1 to 4 years, and positive for FeCov by Real-time PCR on fecal sample. Two microcaps of probiotic formulation containing billion bacteria were administered to all cat once a day for 60 consecutive days. After probiotic administration, clinical conditions and FeCov viral load was assessed by Real-time PCR on fecal samples. All animals did not present alteration in the clinical condition at T1 (after probiotic administration); seventeen out of 25 cats tested negative at the end of the study, while the remaining 8 cats tested positive at the end of the study. The results of the present study suggest that high concentrations of live probiotics supplementation are well-tolerated and may poten-tially reduce the fecal FeCoV viral load.

Keywords

FeCov; cat; Birmanian; probiotic; fecal viral-load

Subject

Medicine and Pharmacology, Veterinary Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (1)

Comment 1

Received: 20 November 2023
Commenter: SARA MANGIATERRA
Commenter's Conflict of Interests: Author

Comment: In according with Editor suggestion, we modified tha main text in the abstract, changing the numbering of materials and methods, checking bibliography n.25 and n.26. We have also added a missing section on conflicts of interest. All changes are highlighted in yellow.

+ Respond to this comment

Not displayed online.

Importance: How significant is the paper to the field?

Outstanding/highlight paper

Significant contribution

Incremental contribution

No contribution

I am not qualified to judge

Soundness of evidence/arguments presented:

Conclusions well supported

Most conclusions supported (minor revision needed)

Incomplete evidence (major revision needed)

Hypothesis, unsupported conclusions, or proof-of-principle

I am not qualified to judge

Please leave your comment to this article below.

Mathematical equations can be typed in either LaTeX formats \\[ ... \\] or $$ ... $$, or MathML format <math> ... </math>. Try the LaTeX or MathML example.

Type equation:

Preview:

Copy equation into message below

Close menu

Please click a symbol to insert it into the message box below:

Please enter the link here:

Please enter a valid URL

Optionally, you can enter text that should appear as linked text:

Copy link into message below

Close menu

Please enter or paste the URL to the image here (please only use links to jpg/jpeg, png and gif images):

Please enter a valid URL

Copy image into message below

Close menu

Type author name or keywords to filter the list of references in this group (you can add a new citation under Bibliography):

No existing citations in Discussion Group

Wikify editor is a simple editor for wiki-style mark-up. It was written by MDPI for Sciforum in 2014. The rendering of the mark-up is based on Wiky.php with some tweaks. Rendering of mathematical equations is done with MathJax. Please send us a message for support or for reporting bugs.

Close menu

Please declare any conflicts of interest you may have with this paper, financial or otherwise.

I do not have a conflict of interest

I would like to declare a conflict of interest

Display my name on the website Send my name and email address to the authors

Captcha

Renew

I accept the following conditions:

Comments must follow the standards of professional discourse and should focus on the scientific content of the article. Insulting or offensive language, personal attacks and off-topic remarks will not be permitted. Comments must be written in English. Preprints reserves the right to remove comments without notice. Readers who post comments are obliged to declare any competing interests, financial or otherwise.

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)

* All users must log in before leaving a comment

what’s this?

Add a record of this review to Publons to track and showcase your reviewing expertise across the world’s journals.

Downloads 0

Comments 1

Metrics 0

Get PDF Cite Share 0

Bookmark BibSonomy Mendeley Reddit Delicious

Alerts

Notify me about updates to this article or when a peer-reviewed version is published.

Preprints.org is a free preprint server subsidized by MDPI in Basel, Switzerland.

MDPI Initiatives

SciProfiles
Sciforum
Encyclopedia
MDPI Books
Scilit
Proceedings
JAMS

Important links

How it Works
Advisory Board
FAQ
Friendly Journals
Instructions for Authors
About
Statistics

Choose the area that interest you and we will send you notifications of new preprints at your preferred frequency.

Disclaimer

We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.

RSS feed for

Preprints: The Multidisciplinary Preprint Platform

Paste the URL in your RSS reader:

https://www.preprints.org/rss

If you want to subscribe our website in subject-wide, you could find the URL by choosing in the following:

https://www.preprints.org/rss

Please note that by using ScienceDirect RSS feeds, you agree to our Terms of Use and Privacy Policy.