Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Qualitative and Quantitative Analysis of Selected Antibiotics Used in Djibouti Hospitals

Version 1 : Received: 14 November 2023 / Approved: 14 November 2023 / Online: 17 November 2023 (07:56:38 CET)

How to cite: elmi fourreh, A.; Mohamed abdoul-Latif, F.; MOUTI, C. Qualitative and Quantitative Analysis of Selected Antibiotics Used in Djibouti Hospitals . Preprints 2023, 2023110980. https://doi.org/10.20944/preprints202311.0980.v1 elmi fourreh, A.; Mohamed abdoul-Latif, F.; MOUTI, C. Qualitative and Quantitative Analysis of Selected Antibiotics Used in Djibouti Hospitals . Preprints 2023, 2023110980. https://doi.org/10.20944/preprints202311.0980.v1

Abstract

The analysis of drugs is a priority in public health, particularly antibiotics which develop resistance due, among other things, to bad dosages or poor quality of the active substance. In this study, we evaluated eight antibiotics available in health centers in Djibouti through qualitative and quantitative analysis. The tests were based on high-purity reference products. In qualitative analysis by HPLC, only amoxicillin presented two impurity peaks. This observation is found in the dosage of this active ingredient with a value of 83 ±0.6 mg instead of the 500 mg indicated on the label. It will be necessary to diversify the sample’s provenance to seek the origin of this degradation.

Keywords

Analysis; antibiotic; Djibouti; HPLC; spectrophotometer; TLC

Subject

Medicine and Pharmacology, Pharmacy

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