Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The IFSD Score － A Practical Prognostic Model for Invasive Fungal Spondylodiscitis

Chao-Chun Yang
ORCID logo ,
Ming-Hsueh Lee
ORCID logo ,
Chia-Yen Liu
,
Meng-Hung Lin
ORCID logo ,
Yao-Hsu Yang
,
Kuo-Tai Chen
ORCID logo ,
Tsung-Yu Huang
* ORCID logo
Version 1 : Received: 14 November 2023 / Approved: 14 November 2023 / Online: 14 November 2023 (10:24:43 CET)

A peer-reviewed article of this Preprint also exists.

Yang, C.-C.; Lee, M.-H.; Liu, C.-Y.; Lin, M.-H.; Yang, Y.-H.; Chen, K.-T.; Huang, T.-Y. The IFSD Score—A Practical Prognostic Model for Invasive Fungal Spondylodiscitis. J. Fungi 2024, 10, 61. Yang, C.-C.; Lee, M.-H.; Liu, C.-Y.; Lin, M.-H.; Yang, Y.-H.; Chen, K.-T.; Huang, T.-Y. The IFSD Score—A Practical Prognostic Model for Invasive Fungal Spondylodiscitis. J. Fungi 2024, 10, 61.

Abstract

Objectives. Invasive fungal spondylodiscitis (IFSD) is rare and could be lethal in certain circumstances. Previous literature revealed limited data concerning the outcomes. This study aimed to establish a risk-scoring system. Methods. A total of 53 patients were included in the study from a multi-centered database in Taiwan. All the clinicopathological and laboratory data were retrospectively analyzed. Variables strongly related to 1-year mortality were identified using a multivariate Cox proportional hazards model. A receiver operating characteristic curve was used to express the performance of our IFSD scoring model. Results. Five strong predictors were included in the IFSD score: predisposing immunocompromised state, the initial presentation of either radiculopathy or myelopathy, initial laboratory findings of WBC > 12.0 or < 0.4 103/uL, hemoglobin < 8 g/dL, and evidence of candidemia. 1-year mortality rates for patients with IFSD Scores of 0, 1, 2, 3, and 4 were 0%, 16.7%, 56.3%, 72.7%, and 100%, respectively. The area under the curve of the receiver operating characteristic curve was 0.823. Conclusions. We developed a practical scoring model with easily obtained demographic, clinical, and laboratory parameters to predict the probability of 1-year mortality in patients with IFSD. However, more large-scale and international validations would be necessary before this scoring model is commonly used.

Keywords

invasive fungal infection; fungus; candida; aspergillus; spondylodiscitis; osteomyelitis; mortality; chang gung research database

Subject

Medicine and Pharmacology, Clinical Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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