Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Fundamental Role of Oxime and Oxime Ether Moieties in Improving the Physicochemical and Anticancer Properties of Structurally Diverse Scaffolds

Jean Fotie
* ORCID logo ,
Caitlyn M Matherne
,
Jasmine B. Mather
,
Jordan E Wroblewski
,
Khaitlynn Johnson
,
Lara G Boudreaux
,
Alba A Perez
Version 1 : Received: 11 November 2023 / Approved: 13 November 2023 / Online: 14 November 2023 (11:39:13 CET)

A peer-reviewed article of this Preprint also exists.

Fotie, J.; Matherne, C.M.; Mather, J.B.; Wroblewski, J.E.; Johnson, K.; Boudreaux, L.G.; Perez, A.A. The Fundamental Role of Oxime and Oxime Ether Moieties in Improving the Physicochemical and Anticancer Properties of Structurally Diverse Scaffolds. Int. J. Mol. Sci. 2023, 24, 16854. Fotie, J.; Matherne, C.M.; Mather, J.B.; Wroblewski, J.E.; Johnson, K.; Boudreaux, L.G.; Perez, A.A. The Fundamental Role of Oxime and Oxime Ether Moieties in Improving the Physicochemical and Anticancer Properties of Structurally Diverse Scaffolds. Int. J. Mol. Sci. 2023, 24, 16854.

Abstract

The present review explores the critical role of oxime and oxime ether moieties in enhancing the physicochemical and anticancer properties of structurally diverse molecular frameworks. Specific examples are carefully selected to illustrate the distinct contributions of these functional groups to general strategies for molecular design, modulation of biological activities, computational modeling, and structure-activity relationship studies. An extensive literature search was conducted across three databases, including Pub-Med, Google Scholar, and Scifinder, enabling us to create one of the most comprehensive overviews of how oximes and oxime ethers impact antitumor activities within a wide range of structural frameworks. This search focused on various combinations of keywords or their synonyms, related to the anticancer activity of oximes and oxime ethers, structure-activity relationships, mechanism of action, as well as molecular dynamics and docking studies. Each article was evaluated based on its scientific merit and the depth of the study, resulting in 268 cited references and more than 336 illustrative chemical structures carefully selected to support this analysis. As many previous reviews focus on one subclass of this extensive family of compounds, this report represents one of the rare and fully comprehensive assessments of the anti-cancer potential of this group of molecules across diverse molecular scaffolds.

Keywords

Oxime and oxime ether moieties; Anticancer activities; Physicochemical properties; SAR and docking studies

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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